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Jean Husten

Jean Husten,Medicinal Chemistry,Organic Chemistry,Biology

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Jean Husten

Publications: 9 | Citations: 17

Fields: Medicinal Chemistry, Organic Chemistry, Biology

Collaborated with 55 co-authors from 2006 to 2011 | Cited by 109 authors

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Publications (9)

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2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

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Journal: Bioorganic & Medicinal Chemistry Letters - BIOORG MEDICINAL CHEM LETTER , vol. 21, no. 2, pp. 660-663, 2011

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group

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Journal: Bioorganic & Medicinal Chemistry - BIOORGAN MED CHEM , vol. 19, no. 21, pp. 6274-6284, 2011

Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors

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Journal: Bioorganic & Medicinal Chemistry Letters - BIOORG MEDICINAL CHEM LETTER , vol. 21, no. 1, pp. 164-167, 2011

Successful Identification of Glycine Transporter Inhibitors Using an Adaptation of a Functional Cell-Based Assay (Citations: 2)

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Journal: Journal of Biomolecular Screening - J BIOMOL SCREEN , vol. 14, no. 10, pp. 1185-1194, 2009

Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1Methyl4phenyltetrahydropyridine Models (Citations: 7)

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Journal: Journal of Medicinal Chemistry - J MED CHEM , vol. 51, no. 18, pp. 5689-5689, 2008

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Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice (Citations: 5)

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Journal: Biochemical Pharmacology - BIOCHEM PHARMACOL , vol. 80, no. 9, pp. 1407-1417, 2010

Targeting protein kinases in central nervous system disorders (Citations: 10)

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Journal: Nature Reviews Drug Discovery - NAT REV DRUG DISCOV , vol. 8, no. 11, pp. 892-909, 2009

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Co-authors (55)

Journals (5)

Keywords (20)

Jean Husten,Medicinal Chemistry,Organic Chemistry,Biology

Publications (9)

BibTeX | RIS | RefWorks Download

2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group

Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors

Successful Identification of Glycine Transporter Inhibitors Using an Adaptation of a Functional Cell-Based Assay (Citations: 2)

Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1Methyl4phenyltetrahydropyridine Models (Citations: 7)

Citations (17 times by 16 publications)

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

Pathological roles of MAPK signaling pathways in human diseases (Citations: 50)

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours (Citations: 3)

Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice (Citations: 5)

Targeting protein kinases in central nervous system disorders (Citations: 10)


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Jean Husten,Medicinal Chemistry,Organic Chemistry,Biology

Publications (9) BibTeX | RIS | RefWorks Download

Successful Identification of Glycine Transporter Inhibitors Using an Adaptation of a Functional Cell-Based Assay (Citations: 2)

Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1Methyl4phenyltetrahydropyridine Models (Citations: 7)

Pathological roles of MAPK signaling pathways in human diseases (Citations: 50)

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours (Citations: 3)

Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice (Citations: 5)

Targeting protein kinases in central nervous system disorders (Citations: 10)

Publications (9)

BibTeX | RIS | RefWorks Download