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Rudi Pauwels

Rudi Pauwels,Catholic School of Mechelen,Medicinal Chemistry,Biochemistry,Organic Chemistry

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Rudi Pauwels

Catholic School of Mechelen

Publications: 36 | Citations: 523

Fields: Medicinal Chemistry, Biochemistry, Organic Chemistry

Collaborated with 162 co-authors from 1987 to 2005 | Cited by 1367 authors

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Publications (36)

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TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments (Citations: 73)

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Journal: Journal of Virology - J VIROL , vol. 79, no. 20, pp. 12773-12782, 2005

In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1 E )-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine) (Citations: 39)

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Journal: Journal of Medicinal Chemistry - J MED CHEM , vol. 48, no. 6, pp. 1901-1909, 2005

Discovery and selection of TMC114, a next generation HIV1 protease inhibitor (Citations: 36)

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Journal: Journal of Medicinal Chemistry - J MED CHEM , vol. 48, no. 6, pp. 1813-1822, 2005

Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1 (Citations: 13)

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Journal: Journal of Medicinal Chemistry - J MED CHEM , vol. 48, no. 6, pp. 2072-2079, 2005

Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV1 Reverse Transcriptase Inhibitory Activity (Citations: 6)

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Journal: Journal of Medicinal Chemistry - J MED CHEM , vol. 48, no. 6, pp. 1910-1918, 2005

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Citations (523 times by 375 publications)

Insights into the structural function of the complex of HIV1 protease with TMC126: molecular dynamics simulations and free-energy calculations

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Journal: Journal of Molecular Modeling - J MOL MODEL , pp. 1-14, 2012

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival (Citations: 2)

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Journal: Cell , vol. 146, no. 4, pp. 607-620, 2011

Mechanisms of HIV1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (Citations: 1)

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Journal: Molecular Biology - MOL BIOL-ENGL TR , vol. 45, no. 1, pp. 93-109, 2011

Characterization of a Novel Type of HIV1 Particle Assembly Inhibitor Using a Quantitative Luciferase-Vpr Packaging-Based Assay

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Journal: PLOS One , vol. 6, no. 11, 2011

Comparative thermodynamic studies on substrate and product binding of O-Acetylserine Sulfhydrylase reveals two different ligand recognition modes †

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Journal: BMC Biochemistry - BMC BIOCHEM , vol. 12, no. 1, pp. 1-15, 2011

Comments

Co-authors (162)

Journals (9)

Keywords (62)

Rudi Pauwels,Catholic School of Mechelen,Medicinal Chemistry,Biochemistry,Organic Chemistry

Publications (36)

BibTeX | RIS | RefWorks Download

TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments (Citations: 73)

In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1 E )-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine) (Citations: 39)

Discovery and selection of TMC114, a next generation HIV1 protease inhibitor (Citations: 36)

Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1 (Citations: 13)

Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV1 Reverse Transcriptase Inhibitory Activity (Citations: 6)

Citations (523 times by 375 publications)

Insights into the structural function of the complex of HIV1 protease with TMC126: molecular dynamics simulations and free-energy calculations

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival (Citations: 2)

Mechanisms of HIV1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (Citations: 1)

Characterization of a Novel Type of HIV1 Particle Assembly Inhibitor Using a Quantitative Luciferase-Vpr Packaging-Based Assay

Comparative thermodynamic studies on substrate and product binding of O-Acetylserine Sulfhydrylase reveals two different ligand recognition modes †


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Co-authors (162)

Journals (9)

Keywords (62)

Rudi Pauwels,Catholic School of Mechelen,Medicinal Chemistry,Biochemistry,Organic Chemistry

Publications (36) BibTeX | RIS | RefWorks Download

TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments (Citations: 73)

In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1 E )-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine) (Citations: 39)

Discovery and selection of TMC114, a next generation HIV1 protease inhibitor (Citations: 36)

Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1 (Citations: 13)

Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV1 Reverse Transcriptase Inhibitory Activity (Citations: 6)

Citations (523 times by 375 publications)

Insights into the structural function of the complex of HIV1 protease with TMC126: molecular dynamics simulations and free-energy calculations

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival (Citations: 2)

Mechanisms of HIV1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (Citations: 1)

Characterization of a Novel Type of HIV1 Particle Assembly Inhibitor Using a Quantitative Luciferase-Vpr Packaging-Based Assay

Comparative thermodynamic studies on substrate and product binding of O-Acetylserine Sulfhydrylase reveals two different ligand recognition modes †

Publications (36)

BibTeX | RIS | RefWorks Download