,Dna Methylation,DNA methyl,DNA methylations,DNA methylated,DNA methylating,DNA methylator

Dna Methylation
Publications: 8,965| Citation Count: 165,046
Stemming Variations: DNA methyl, DNA methylations, DNA methylated, DNA methylating, DNA methylator
Cumulative Annual
    • DNA methylation is a physiological mechanism regulating both gene expression and genomic stability. Abnormal DNA methylation is observed in neoplastic as well as degenerative disease, and may affect both the whole genome and specific genes. Aberrant DNA methylation has been recently associated to the exposure to carcinogenic chemical compounds. The characterization of DNA methylation abnormalities by modern molecular biology methods may allow the development of new molecular biomarkers of early biological effects...

    G. De Palmaet al. Nuovi indicatori molecolari per la prevenzione della patologia tumoral...

    • DNA methylation is a mark on genomic DNA created by addition of methyl groups to cytosines in CpG dinucleotides. The methylation pattern is correlated with gene activity and constitutes a stable epigenetic situation transmitted through DNA replication and cellular division. The investigations on the functional significance of DNA methylation for differentiation and malignant transformations became a very active area of research within the past two decades...

    JULIA YANEVAet al. DNA methylation and cancer: an overview

    • DNA methylation is an important epigenetic mechanism of transcriptional control. DNA methylation plays an essential role in maintaining cellular function, and changes in methylation patterns may contribute to the development of cancer. Aberrant methylation of DNA (global hypomethylation accompanied by region-specific hypermethylation) is frequently found in tumor cells. Global hypomethylation can result in chromosome instability, and hypermethylation has been associated with the inaction of tumor suppressor genes...

    CINDY D. DAVISet al. DNA Methylation, Cancer Susceptibility, and Nutrient Interactions

    • DNA methylation is an epigenetic modification involved in both normal developmental processes and disease states through the modulation of gene expression and the maintenance of genomic organization. Conventional methods of DNA methylation analysis, such as bisulfite sequencing, methylation sensitive restriction enzyme digestion and arraybased detection techniques, have major limitations that impede high-throughput genome-wide analysis...

    David Serreet al. MBD-isolated Genome Sequencing provides a high-throughput and comprehe...

    • DNA methylation is an epigenetic mechanism regulating patterns of gene expression. Our goal was to see if the assessment of DNA methylation might be a useful tool, when used in conjunction with initial, basic in vitro tests, to provide a more informative preliminary appraisal of the toxic potential of chemicals to prioritize them for further evaluation...

    Rebecca E. Watsonet al. The Value of DNA Methylation Analysis in Basic, Initial Toxicity Asses...

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