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Epidermal Growth Factor Receptor

EGFr,Epidermal Growth Factor Receptor,epidermal growth factor receptors

Epidermal Growth Factor Receptor - EGFr
Publications: 11,168| Citation Count: 196,151
Stemming Variations: epidermal growth factor receptors
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    • The epidermal growth factor receptor (EGFR) is an important determinant of radioresponse, whose elevated expression and activity frequently correlates with radioresistance in several cancers, including non-small cell lung carcinoma (NSCLC)...

    Amit K. Das, et al. Somatic Mutations in the Tyrosine Kinase Domain of Epidermal Growth Fa...

    • The epidermal growth factor receptor (EGFR)3 is a 170 kD transmembrane tyrosine kinase activated by several ligands. It is required for normal mammary development and lactation and is aberrantly expressed in approximately 40% of breast carcinomas, particularly those with a poor prognostic phenotype...

    Stephen B. Fox, et al. The Epidermal Growth Factor Receptor in Breast Cancer

    • The epidermal growth factor receptor (EGFR) is a type I tyrosine kinase receptor that plays a central role in signal transduction pathways that regulate key cellular functions in epithelial malignancies.After ligand binding, EGFR homoor heterodimerizes with other members of the EGFR family of receptors, such as HER-2, and activates a signaling cascade that participates in tumor proliferation, angiogenesis, survival, and invasion/metastasis (61)...

    Michalis V. Karamouzis, et al. Update on the Role of EGFR Inhibitors in Cancer Therapeutics

    • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase involved in the regulation of growth in many animal cells, including cancer cells. Phosphorylation of specific tyrosine residues within the cytoplasmic domain of EGFR is part of the initial activation process that occurs upon ligand binding, and these phosphotyrosine residues subsequently serve as docking sites for intracellular signaling molecules...

    Lin Guo, et al. Studies of ligand-induced site-specific phosphorylation of epidermal g...

    • The epidermal growth factor receptor (EGFR) is a cytoskeleton-binding protein. Although purified EGFR can interact with actins in vitro and normally at least 10% of EGFR exist in the insoluble cytoskeleton fraction of A431 cells, interaction of cytosolic EGFR with actin can only be visualized by fluorescence resonance energy transfer when epidermal growth factor presents in the cell medium. Results indicate that the correct orientation between EGFR and actin is important in the signal transduction process...

    Wei Song, et al. Epidermal growth factor induces changes of interaction between epiderm...

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