Academic
Keywords
insulin-like growth factor i

,insulin-like growth factor i,insulin like growth factor I,Insulin like Growth Factors I,insuline like growth factor I

insulin-like growth factor i
Publications: 9,382| Citation Count: 155,556
Stemming Variations: insulin like growth factor I, Insulin like Growth Factors I, insuline like growth factor I
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    • Insulin-like growth factor-I (IGF-I) is a survival factor for preimplantation mammalian embryos exposed to stress. One stress that compromises preimplantation embryonic development is elevated temperature (i.e., heat shock). Using bovine embryos produced in vitro as a model, it was hypothesized that IGF-I would protect preimplantation embryos by reducing the effects of heat shock on total cell number, the proportion of blastomeres that undergo apoptosis, and the percentage of embryos developing to the blastocyst stage...

    F. D. Jousanet al. Insulin-like Growth Factor-I as a Survival Factor for the Bovine Preim...

    • Insulin-like growth factor-I (IGF-I) is a potent stimulator of vascular smooth muscle cell (SMC) migration, a process that contributes to the accumulation of SMC within atherosclerotic lesions. Our previous studies have shown that IGF-I increases the affinity of the aVb3 integrin toward ligands and that occupancy of this integrin is indispensable for IGF-I to stimulate cell migration...

    YUMI IMAIet al. Roles of Phosphatidylinositol 3Kinase and Mitogen-Activated Protein Ki...

    • Insulin-like growth factor-I (IGF-I) is a central mediator of cell growth, differentiation and metabolism. Structural characterization of the protein has been hampered by a combination of internal dynamics and self-association that prevent crystallization and produce broad NMR resonances...

    Nicholas J. Skeltonet al. Phage display-derived ligands provide structural insight into insulin-...

    • Insulin-like growth factor-I (IGF-I) is a polypeptide hormone that can influence growth, differentiation, and survival of cells expressing the cognate type 1 receptor (IGF-IR)...

    Brent W. Sutherlandet al. Conditional Deletion of Insulin-like Growth Factor-I Receptor in Prost...

    • Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation of MCF-7 breast cancer cells, and cotreatment with the phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 and the antiestrogen ICI 182780 inhibits IGF-I-induced growth. The role of estrogen receptor (ER) in mediating responses induced by IGF-I was investigated in cells transfected with small inhibitory RNA for ER (iER)...

    S Zhanget al. Role of estrogen receptor (ER)   in insulin-like growth factor (IGF)-I...

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