,p-glycoprotein,P Glycoprotein,P glycoproteins

p-glycoprotein
Publications: 7,893| Citation Count: 119,209
Stemming Variations: P Glycoprotein, P glycoproteins
Cumulative Annual
    • P-glycoprotein (P-gp) on activated lymphocytes is an adenosine triphosphate (ATP)-binding cassette transporter that causes drug resistance by exclusion of intracellular drugs in patients with active rheumatoid arthritis (RA)...

    Shizuyo Tsujimuraet al. Etanercept overcomes P-glycoprotein-induced drug resistance in lymphoc...

    • P-glycoprotein (Pgp) is an inducible transmembrane protein that functions as an ATP-dependent efflux pump. Pgp is normally expressed in two types of cells: specialized epithelial cells with secretory/excretory functions (e.g., proximal renal tubules) and specialized endothelial cells (e.g., the capillary endothelial cells of the blood-brain barrier). In normal tissues, Pgp could exert a cytoprotective effect by facilitating excretion of drugs. It follows that inhibition of Pgp would alter the pharmacokinetics of drugs, like doxorubicin, in cells that express Pgp...

    Christine S. Hugheset al. Modulation of doxorubicin concentration by cyclosporin A in brain and ...

    • P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many drugs, particularly cancer chemotherapeutics. Multidrug resistance (MDR) is caused largely by the efflux of therapeutics out of the tumor cell by Pgp, resulting in reduced efficacy of chemotherapy...

    Er-jia Wanget al. The Farnesyl Protein Transferase Inhibitor SCH66336 Is a Potent Inhibi...

    • P-glycoprotein (P-gp) is a transporter protein associated with multidrug resistance to certain anticancer drugs (MDR). Initially P-gp was identified by its overexpression in multidrug resistant tumor cells. P-gp is also expressed in a wide range of normal tissues including liver, intestines, blood-brain barrier and kidneys. P-gp secrets a large number of endogenous and xenobiotic compounds from the intracellular to the extracellular domain by an ATP-dependent process...

    Trabajos de Revisiónet al. PHYSIO-PHARMACOLOGICAL IMPLICATIONS OF P-GLYCOPROTEIN IN DOMESTIC ANIM...

    • P-glycoprotein (Pgp) is a plasma membrane protein that was first characterised in multidrug resistant cell lines. The occurrence of Pgp in clinical tumors has been widely studied. Recent investigations have begun to focus on the relationship between Pgp detection in tumors and treatment outcome. In several types of tumors, detection of Pgp correlates with poor response to chemotherapy and shorter survival...

    Grace Bradleyet al. P-glycoprotein, multidrug resistance and tumor progression

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