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Spontaneously Hypertensive Rat

SHR,Spontaneously Hypertensive Rat,spontaneously hypertensive rats,spontaneous hypertensive rats,spontaneously hypertension rat,spontaneous hypertensi

Spontaneously Hypertensive Rat - SHR
Publications: 8,266| Citation Count: 62,854
Stemming Variations: spontaneously hypertensive rats, spontaneous hypertensive rats, spontaneously hypertension rat, spontaneous hypertensive rat, spontaneous hypertension rats
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    • The spontaneously hypertensive rat (SHR) is an animal model of genetic hypertension which develops heart failure with aging, similar to man. The consistent pattern of a long period of stable hypertrophy followed by a transition to failure provides a useful model to study mechanisms of heart failure with aging and test treatments at differing phases of the disease process...

    Oscar H. L. Binget al. Studies of Prevention, Treatment and Mechanisms of Heart Failure in th...

    • The spontaneously hypertensive rat (SHR) is an important animal model of human essential hypertension. During the first month of life, increased retention of sodium is present in the SHR which appears to be mediated by the renin-angiotensin system. The present review will discuss the role that increased activity of the renin-angiotensin system plays in sodium/body fluid regulation during early development...

    R. F. Kirbyet al. Regulation of sodium and body fluid homeostasis during development: Im...

    • The spontaneously hypertensive rat (SHR) is an accepted model for attention-deficit hyperactivity disorder (ADHD) since it displays the major symptoms of ADHD (hyperactivity, impulsivity, and poor performance in tasks that require sustained attention)...

    Molupe Lehohlaet al. NMDA Receptor Function in the Prefrontal Cortex of a Rat Model for Att...

    • The spontaneously hypertensive rat (SHR) is an excellent model of essential hypertensive disease. Hyperreactivity has been postulated as a contributing factor in the development of high blood pressure in the SHR and in man. In the maturing organism recurring hypertensive stress responses may promote permanent vascular changes and result in a fixed hypertension. Simple behavioral activity and emotionality rating scales were used to compare a large number of SHR with equally large groups of closely-related and distantly-related normotensive rats...

    Carl F. Schaeferet al. Behavioral hyperreactivity in the spontaneously hypertensive rat compa...

    • The spontaneously hypertensive rat (SHR) is a good model to study several diseases such as the attention-deficit hyperactivity disorder, cardiopulmonary impairment, nephropathy, as well as hypertension, which is a multifactor disease that possibly involves alterations in gene expression in hypertensive relative to normotensive subjects...

    Merari F. R. Ferrariet al. Gene Expression Profiling of Cultured Cells From Brainstem of Newborn ...

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