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Tau Protein

,Tau Protein,tau proteins

Tau Protein
Publications: 1,932| Citation Count: 37,575
Stemming Variations: tau proteins
Cumulative Annual
    • Tau protein is a microtubule-associated molecule playing a crucial role in maintenance of neuronal integrity and in many neurodegenerative processes; its pathology has become a hallmark feature at the tissue level. The aim of the study was to estimate total tau and phospho-tau (Thr181) concentrations in cerebrospinal fluid of healthy population. Cerebrospinal fluid samples were taken from 129 subjects (age 18-77 years) without known neurologic or psychiatric condition. Both total-tau and phosphotau levels showed significant correlation with age, which was more pronounced in older population...

    J. JAWORSKI, et al. Total-tau and Phospho-tau(181Thr) in Cerebrospinal Fluid of Neurologic...

    • Tau protein is a brain microtubule–associated protein having 79 putative phosphorylatable sites that could be modified by serine/threonine protein kinases. This phosphorylation can be divided in two types, depending whether the modified residue is phosphorylated by proline-directed or by non-proline-directed protein kinases...

    Jesús Avila, et al. Tau Phosphorylation

    • Tau protein is a neuronal microtubule associated protein, which localizes primarily in the axon. It plays a major role in promoting microtubule assembly, stabilizing microtubules and maintaining the normal morphology of the neurons. Structurally tau is a heterogenous molecule due to several posttranslational modifications. Tauopathies are a group of disorders that are the consequence of abnormal tau phosphorylation, abnormal levels of tau, abnormal tau splicing, or mutations in the tau gene...

    R. Mathew, et al. Tau and Tauopathies

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Publications (1932)

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