Academic
Keywords
Tissue Plasminogen Activator

TPA,Tissue Plasminogen Activator,tissue plasminogen activity,tissue plasminogen activators

Tissue Plasminogen Activator - TPA
Publications: 4,055| Citation Count: 49,129
Stemming Variations: tissue plasminogen activity, tissue plasminogen activators
Cumulative Annual
    • Tissue plasminogen activator (tPA) is a serine protease that converts plasminogen to plasmin and can trigger the degradation of extracellular matrix proteins. In the nervous system, under noninflammatory conditions, tPA contributes to excitotoxic neuronal death, probably through degradation of laminin...

    Katerina Akassoglouet al. Tissue Plasminogen Activator-mediated Fibrinolysis Protects Against Ax...

    • Tissue plasminogen activator (tPA) is an essential component of the proteolytic cascade that lyses blood clots. Various studies also suggest that tPA plays important roles in peripheral nerve regeneration...

    Changchun Linget al. Disruption of tissue plasminogen activator gene reduces macrophage mig...

    • Tissue plasminogen activator (t-PA) is a glycoprotein that converts plasminogen to plasmin, which cleaves the gel form of fibrin to soluble fibrin degradation products. Recombinant t-PA (Activase® t-PA) is currently used as a thrombolytic agent in the treatment of acute myocardial infarction. Using recombinant DNA technology, the protein sequence can be altered, possibly improving the function of t-PA. Numerous investigators have taken different approaches to the design and evaluation of t-PA variants...

    Bruce A. Keytet al. Molecular Approaches to The Design of New Thrombolytic Agents

    • Tissue plasminogen activator (tPA) is the main activator of plasminogen into plasmin in the brain where it may have beneficial roles but also neurotoxic effects that could be plasmin dependent or not. Little is known about the substrates and pathways that mediate plasmin-independent tPA neurotoxicity...

    Manel G Medinaet al. Tissue plasminogen activator mediates amyloid-induced neurotoxicity vi...

    • Tissue plasminogen activator (tPA) is the major plasminogen activator responsible for dissolving blood clots found in blood vessels. However, elevated concentrations of tPA antigen were found to be related to adverse events in patients with coronary artery disease (CAD). Considerable controversy about the significance of these results exists. The goal of this cross-sectional study was to identify independent determinants for tPA antigen concentrations in patients with CAD, to possibly clarify the above paradoxical relationship...

    Alexander Geppertet al. Concentration of Endogenous tPA Antigen in Coronary Artery Disease Rel...

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