,X-ray Crystallography,X ray crystallography,x rays crystallography

X-ray crystallography is the method of choice for determlning the 3-D structure of large macromolecules at a high enough resolution. The rate limiting step in structure determination is the crystallization itself. It takes anywhere between a few weeks to several years to obtain macromolecuiar crystals that yield good diffraction patterns...

Daniel N. Hennessy, et al. Induction of Rules for Biological Macromolecular Crystallization