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Acute Myeloid Leukemia

AML,Acute Myeloid Leukemia,acute myeloid leukemias

Acute Myeloid Leukemia - AML
Publications: 8,279| Citation Count: 111,899
Stemming Variations: acute myeloid leukemias
Cumulative Annual
    • Acute myeloid leukemia (AML) is a heterogenous disorder that results from a block in the differentiation of hematopoietic progenitor cells along with uncontrolled proliferation. In approximately 60% of cases, specific recurrent chromosomal aberrations can be identified by modern cytogenetic techniques. This cytogenetic information is the single most important tool to classify patients at their initial diagnosis into three prognostic categories: favorable, intermediate, and poor risk...

    Tara K Gregory, et al. Molecular prognostic markers for adult acute myeloid leukemia with nor...

    • Acute myeloid leukemia (AML) is a heterogeneous neoplastic disease characterized by deregulated proliferation of myeloid precursor cells combined with an arrest in the differentiation process. The abnormal survival advantage of transformed immature myeloid precursors further contributes to a marked impairment of the functional maturation of the various myeloid cell lineages. Intensive studies over the past 20 yr have resulted in the identification of leukemia-specific cytogenetic abnormalities, which provided considerable insight into the underlying pathogenesis of AML...

    Blanca Scheijen, et al. Activated FLT3 Receptor Tyrosine Kinase as a Therapeutic Target In Leu...

    • Acute myeloid leukemia (AML) is a common hematopoietic malignancy characterized by the abnormal proliferation and differentiation of myeloid progenitor cells. The fusion geneAML1-ETO is a product of t(8;21)(q22;q22) chromosomal translocation, one of the most common chromosomal translocations associated with acute myeloid leukemia Therefore, analyzing the molecular mechanism of AML1-ETO in the process of AML development will provide valuable information to normal hematopoiesis and leukemogenesis...

    Dong-Er Zhang. Molecular pathogenesis of AML (mouse models of acute myeloid leukemia ...

    • Acute myeloid leukemia (AML) is a clonal disease characterized by heterogeneous involvement of hematopoietic stem cell/ progenitor cell populations...

    Jessica A. Pollard, et al. FLT3 internal tandem duplication in CD34/CD33 precursors predicts poor...

    • Acute myeloid leukemia (AML) is a clonal disorder characterized by abnormal proliferation of myeloid cell precursors...

    Gunnel Sundström, et al. Bone marrow hyaluronan distribution in patients with acute myeloid leu...

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