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Keywords
multiple endocrine neoplasia type 2

MEN2,multiple endocrine neoplasia type 2,multiples endocrines neoplasias type 2

multiple endocrine neoplasia type 2 - MEN2
Publications: 319| Citation Count: 5,070
Stemming Variations: multiples endocrines neoplasias type 2
Cumulative Annual
    • Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare hereditary complex disorder characterized by the presence of medullary thyroid carcinoma (MTC), unilateral or bilateral pheochromocytoma (PHEO) and other hyperplasia and/or neoplasia of different endocrine tissues within a single patient. MEN2 has been reported in approximately 500 to 1000 families worldwide and the prevalence has been estimated at approximately 1:30,000...

    Francesca Mariniet al. Multiple endocrine neoplasia type 2

    • Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant tumour syndrome caused by germline-activating mutations of the RET proto-oncogene. It has a strong penetrance of medullary thyroid carcinoma (MTC) and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism (MEN2A) within a single patient or family...

    Friedhelm Raueet al. Genotype-phenotype relationship in multiple endocrine neoplasia type 2...

    • Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant inherited tumor syndrome caused by RET proto-oncogene germline mutations (RET)...

    MARCELO A. C. G. DOS SANTOSet al. artigo original Screening of RET Gene Mutations in Multiple Endocrine ...

    • Multiple endocrine neoplasia type 2 is a syndrome characterized by medullary thyroid carcinoma and pheochromocytomas. The identification of RET proto-oncogene mutations in multiple endocrine neoplasia type 2 has provided a precise method for identifying gene carriers. Additionally, the identification of these mutations has allowed characterizing the clinical expression and the severity of medullary thyroid carcinoma and proper prophylactic treatment and follow-up...

    Camilo Jiménezet al. Neoplasia endocrina múltiple tipo 2: un ejemplo para la prevención del...

    • Multiple endocrine neoplasia type 2 (MEN2) is a autosomal dominat inherited tumour-syndrome caused by germline activating mutations of the RET proto-oncogene on chromosome 10. It is clinically characterized by the presence of medullary thyroid carcinoma (MTC), bilateral pheochromocytoma and primary hyperparathyroidism (MEN2A) within a single patient. Three distinct clinical forms have been described depending on the phenotype: the classical MEN 2A, MEN 2B, an association of MTC, pheochromocytoma and mucosal neuroma, (FMTC) familial MTC with a low incidence of other endocrinopathies...

    Friedhelm Raueet al. Update multiple endocrine neoplasia type 2

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