Academic
Keywords
Urokinase Plasminogen Activator

uPA,Urokinase Plasminogen Activator,urokinase plasminogen activation,urokinase plasminogen activators

Urokinase Plasminogen Activator - uPA
Publications: 913| Citation Count: 11,226
Stemming Variations: urokinase plasminogen activation, urokinase plasminogen activators
Cumulative Annual
    • Urokinase plasminogen activator (UK-PA) is a serine protease impli cated in cancer invasion and metastasis. In this investigation, patients with breast cancers containing high levels of UK-PA antigen had signif icantly higher risk of early disease recurrence and shorter overall survival than did patients with low levels of the protein...

    Michael J. Duffyet al. Urokinase-Plasminogen Activator, a New and Independent Prognostic Mark...

    • Urokinase plasminogen activator (uPA) is an important regulator of fibrinolysis in synovial fluid. An increase of uPA activity and expression of its receptor have been reported in joints of patients with rheumatoid arthritis (RA). The aim of the present study was to assess the arthritogenic capacity of uPA and the mechanisms by which this effect is mediated. uPA was injected into the knee joints of healthy mice, and morphological signs of arthritis were assessed 4 days after the injection...

    Tao Jinet al. Urokinase, a constitutive component of the inflamed synovial fluid, in...

    • Urokinase plasminogen activator (uPA) is a serine protease causally involved in cancer invasion and metastasis. In this study, high concentrations of uPA in primary breast cancers were independently associated with both a shortened disease-free interval and overall survival. For the disease-free interval as endpoint, uPA was a stronger indicator of outcome than lymph node status, whereas for overall survival, nodal status was stronger than uPA...

    Michael J. Duffyet al. Urokinase plasminogen activator: a prognostic marker in breast cancer ...

    • Urokinase plasminogen activator (uPA) is a proteolytic enzyme involved in degradation of the extracellular matrix during cancer invasion. The levels of uPA and its inhibitor PAI-1 in tumor extracts have previously been demonstrated to be of prognostic value in breast cancer as well as other types of cancer...

    E. Rønneet al. Urokinase receptor in breast cancer tissue extracts. Enzyme-linked imm...

    • Urokinase plasminogen activator (uPA) is a serine protease which has frequently been implicated in the process of tumor cell invasion and metastasis...

    Beric R. Hendersonet al. Transcriptional and Posttranscriptional Activation of Urokinase Plasmi...

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