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The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig,10.1051/vetres:2005017,Veterinary Research,

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig   (Citations: 9)
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Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 µg/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 ± 8 µg/mL (n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection. acute phase proteins / pigs / infection Streptococcus suis
Journal: Veterinary Research - VET RES , vol. 36, no. 4, pp. 657-664, 2005
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    • ...We have characterized the APP response in pigs undergoing experimental infections [11-15] and the correlation between APP concentrations and disease in pigs in herds of different health status has also been studied [16-22]...
    • ...The ELISA was developed using 50 mM citric acid, pH 4.0, 0.1 mM ABTS (2,2 Azino-bis(3-ethylbenzthiazoline-6sulfonic acid)), 0.01% H2O2 as a color substrate and the absorbance read at 405 nm. For the measurement of TTR [11,15], microtiter plates were coated with serum samples and purified human TTR (standard)(Sigma-Aldrich, Poole, UK) and blocked with non-fat dried milk in assay buffer (0.12 M NaCl, 0.02 M Na2HPO4, 0.1% (v/v) Tween 20, pH ...
    • ...The data reported here give aw ealth of information on the response of different APPs to different infections in the pig, complementing earlier studies in experimental models [11-15] and suggesting ways of using APPs for monitoring infections when type of the infection(s) as well as the infection starting points are unknown...

    Peter MH Heegaardet al. Optimal combinations of acute phase proteins for detecting infectious ...

    • ...APP such as haptoglobin, transthyretin, alpha-1 acid glycoprotein (AGP) and C-reactive protein (CRP) have also been shown to act as potential indicators of animal and farm health status [15-19]...

    Mary Clappertonet al. Traits associated with innate and adaptive immunity in pigs: heritabil...

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