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Salivary a-Amylase: RoleinDental Plaque andCaries Formation

Salivary a-Amylase: RoleinDental Plaque andCaries Formation,Frank A. Scannapieco,Guillermo Torres,J. Levine

Salivary a-Amylase: RoleinDental Plaque andCaries Formation   (Citations: 2)
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Salivary a-amylase, oneofthemostplentiful components inhumansaliva, hasatleast three distinct biological functions. Theenzymatic activity ofa-amylase undoubtedly plays arole incarbohydrate digestion. Amylase insolution binds withhighaffinity toaselected groupoforal streptococci, afunction that may contribute tobacterial clearance andnutrition. The fact that a-amylase isalso found inacquired enamel pellicle suggests arole intheadhesion ofa-amylase-binding bacteria. All ofthese biological activities seemtodepend on anintact enzymeconformation. Binding ofa-amylase tobacteria andteeth may haveimportant implications fordental plaque andcaries formation. a-Amylase boundtobacteria inplaque may facilitate dietary starch hydrolysis toprovide additional glucose formetabolism byplaque microorganisms inclose proximity tothetooth surface. Theresulting lactic acid produced may beadded tothepoolofacidinplaque tocontribute totooth demineralization.
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