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ß-Adrenergic Receptor Blockade in Chronic Heart Failure
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ß-Adrenergic Receptor Blockade in Chronic Heart Failure   (Citations: 300)
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Published in 2010.
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    • ...On the basis of the LVEF changes detected in previous similar studies [6, 26, 27], and assuming a 15% frequency of the patients homozygous for Glu27Glu (the least frequent of the 3 polymorphisms tested), we calculated that the enrollment of 175 patients would provide a 80% power to detect an absolute difference of 5 units (alpha level 0.05) in the change in the LVEF after carvedilol administration between the patients homozygous for ...
    • ...Increased cardiac adrenergic drive is one of the major determinants of the progression of LV dysfunction and of the poor outcomes of the patients with HF [12, 13]...
    • ...Carvedilol is a non selective beta-blocker and its effects on beta-2 AR may play an important role [12, 13]...

    Marco Metra, et al. Role of Beta-Adrenergic Receptor Gene Polymorphisms in the Long-Term E...

    • ...That b-AR signaling is detrimental to cardiac function is supported by clinical studies in humans showing that blockade of b-AR receptors improves survival in heart failure patients [19], and by studies on transgenic mice, showing that chronic activation of the cAMP-PKA pathway by cardiac-specific overexpression of b-AR, Gsa,...

    Linda C Enns, et al. Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-ind...

    • ...This is of particular interest for cardiovascular physiology as chronic stimulation of βAR signaling and its downstream effectors such as PKA eventually leads to cardiac hypertrophy and heart failure [72, 73]...

    David Rohde, et al. S100A1: A Multifaceted Therapeutic Target in Cardiovascular Disease

    • ...Metoprolol and bisoprolol are β1 selective and have modest inverse activity (i.e., they decrease the spontaneous activity of the receptor in the absence of an agonist), whereas carvedilol is nonselective, shows no inverse activity, dissociates slowly from the receptor, and is a radical scavenger and α1-receptor antagonist [8, 9] (Table 1). All three compounds lead to similar clinical results, but carvedilol was superior to metoprolol in a ...

    Junichi Azuma, et al. Chronic heart failure: β-blockers and pharmacogenetics

    • ...Bristow et al. [20] demonstrated that chronic adrenergic stimulation of the injured myocardium promotes myocyte hypertrophy, abnormal signal transduction, and cell apoptosis due at least in part to increased production of cytokine mediators such as tumor necrosis factor-α and interleukins 6 and 1β [20,21]...
    • ...Bristow et al. [20] demonstrated that chronic adrenergic stimulation of the injured myocardium promotes myocyte hypertrophy, abnormal signal transduction, and cell apoptosis due at least in part to increased production of cytokine mediators such as tumor necrosis factor-α and interleukins 6 and 1β [20,21]...

    Robert H. Neumayr, et al. β-Adrenergic receptor blockers and heart failure risk after myocardial...

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