Academic
Publications
Carcinoma de célula pequeña pulmonar combinado con adenocarcinoma y carcinoma escamoso Pulmonary small cell carcinoma combined with adenocarcinoma and squamous carcinoma

Carcinoma de célula pequeña pulmonar combinado con adenocarcinoma y carcinoma escamoso Pulmonary small cell carcinoma combined with adenocarcinoma and

Carcinoma de célula pequeña pulmonar combinado con adenocarcinoma y carcinoma escamoso Pulmonary small cell carcinoma combined with adenocarcinoma and squamous carcinoma  
BibTex | RIS | RefWorks Download
SUMMARY Introduction: Small cell carcinoma (SCC) represents about 20-25% of all malignant lung tumors. This type of tumor exhibits some peculiarities such as its rapid progres- sion, aggressive metastatic behavior, central localization and its association with paraneoplastic syndromes. SCC is classified as pure, mixed with large-cell carcinoma and combined with adenocarcinoma and/or squamous carcino- ma. Case: A 58-year-old man with a thoracic mass found in a routine x-ray. The bronchoscopic studies (cytology, bron- choalveolar aspirate and biopsy) did not revealed any evi- dence of malignancy. The patient eventually underwent sur- gical resection of his lung mass, and on gross examination, the specimen received showed a well-defined white peri- bronchial mass (measuring 4.0 × 3.0 cm in greatest dimen- sions). Microscopically, the tumor showed a combination of three well-differentiated cellular patterns, with a predomi- nance of a small cell pattern over adenocarcinoma and squa- mous patterns. Two lymph nodes were also identified, and they appeared to be infiltrated by tumor, with predominan- ce of the adenocarcinoma pattern. Conclusion: This case is interesting because SCC combined with non-small cell car- cinoma represents less than 1% of all SCC, and the combi- ned growth of the three different patterns is even rarer. Tre- atment and survival of SCC combined with non-small cell carcinoma are the same as pure SCC, both types have a bet- ter prognosis than SCC mixed with large-cell carcinoma. RESUMEN Introducción: De las tumoraciones malignas pulmona- res, el carcinoma de célula pequeña (CCP) se presenta en un 20-25% de los casos. Se caracteriza por una rápida progre- sión y gran poder metastásico, disposición central pulmonar y asociación a síndromes paraneoplásicos. Se reconocen tres subgrupos: CCP puro, carcinoma mezclado con células grandes, y el CCP combinado con carcinoma escamoso y/o adenocarcinoma. Caso clínico: Paciente varón de 58 años con hallazgo casual de masa en la radiología de tórax. La broncoscopia (citología, BAS y biopsia) resultó negativa para células malignas. Ante las características radiológicas muy sugestivas de malignidad se realizó neumonectomía. En el estudio de la pieza quirúrgica se observó una tumora- ción peribronquial blanquecina de 4 × 3 cm bien delimita- da. El estudio microscópico mostró proliferación mixta con tres claros patrones bien diferenciados predominando el patrón de tipo célula pequeña sobre el adenocarcinomatoso y el escamoso. Dos ganglios linfáticos mostraron infiltra- ción tumoral de patrón glandular. Conclusión: La impor- tancia de este caso radica en su rareza, ya que el CCP com- binado representa menos del 1% del total de CCP, siendo todavía más rara la presencia de los tres patrones histológi- cos descritos. La supervivencia y tratamiento es similar al CCP puro, mostrando un mejor pronóstico que el CCP mez- clado con células grandes. Palabras claves: carcinoma de célula pequeña, mixto, combinado, carcinoma no-célula pequeña, pulmón.
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.