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A general view: Structure and function of the subunits of E. coli RNA polymerase

A general view: Structure and function of the subunits of E. coli RNA polymerase,Nihal Büyükuslu

A general view: Structure and function of the subunits of E. coli RNA polymerase  
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The DNA-dependent RNA polymerases are widespread throughout nature. E. coli RNA polymerase, one of the most well characterized polymerase, consists of two major forms, core enzyme with subunit stoichiometry of 2' and holoenzyme which contains an additional  subunit to core enzyme. E. coli RNA polymerase plays a central role in transcription. While the core enzyme catalyses the elongation and termination of transcription, to initiate core enzyme needs to combine with  subunit. The three dimensional structure of this multimeric enzyme revealed a thumb-like projection. Using the electron microscope, Tichelar and Heel (1990) proposed a model that is in agreement with both  and ' together constituting a V-like structure and  dimer associates at the short ends, while  is positioned within the concave side of the core, next to the dimer. In this review, the structure and related functions of the subunits of E. coli DNA-dependent RNA polymerase is presented based on several researches and reviews. Considering biochemical and genetic studies on the RNA polymerase of E. coli, a genetic walk on the subunits is summarized.
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