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Placebo Washout in Trials of Antipsychotic Drugs

Placebo Washout in Trials of Antipsychotic Drugs,Schizophrenia Bulletin,Jan Volavka,Thomas B. Cooper,Eugene M. Laska,Morris Meisner

Placebo Washout in Trials of Antipsychotic Drugs   (Citations: 3)
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For antipsychotic phase 3 clinical trials, we compare the relative mer- its of a placebo washout period with an alternate design strategy using a low-dose antipsychotic treatment Evaluations are made with respect to the achievement of specific clini- cal trial design goals including the effect on power for detecting between-treatment and within-treat- ment pre-post differences. The rela- tive merits of these two designs are discussed separately for those patients who enter the initial lead- in period after withdrawal from pre- vious antipsychotic medication and for those not on medication imme- diately before that period.
Journal: Schizophrenia Bulletin - SCHIZOPHRENIA BULL , vol. 22, no. 4, pp. 567-576, 1996
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