Effects of solvent properties on the Soxhlet extraction of diterpenoid lactones from Andrographis paniculata leaves
A solid-liquid extraction was performed for the leaves of Andrographis paniculatain order to obtain two bioactive components, andrographolide and deoxyandrographolide. The problem of hydrolysable components and solvent removal difficulties in the conventional extraction led us to study further the effects of solvent properties on the conventional extraction using Soxhlet method in order to determine the best solvent or solvent mixture for high extraction yield of A. paniculata. This solvent selection is very important prior to alternative extraction methods since it can be used as a pre- extraction solvent, main solvent, or co-solvent. Based on the yield of extract and andrographolide and deoxyandrographolide content, methanol was found to be the best solvent.
Published in 2009.