Basic local alignment search tool

Basic local alignment search tool,Nucleic Acids Research,Stephen F. Altschul,Warren Gish,Webb C. Miller,Eugene W. Myers,David J. Lipman

Basic local alignment search tool   (Citations: 21081)
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A new approach to rapid sequence comparison, basic local alignment search tool (BLAST),directly approsimates alignments that optimize a measure of local similarity, the maximal segment pair (3ISP) score. Recent mathematical results on the stochastic properties of MSP scores allow an anallrsis of the performance of this method as well as the statistical significance of alignments it generates. The basic algorithm is simple and robust; it can be implemented in a number of ways and applied in a variety of contexts including straightforward DKB and protein sequence database searches, motif searches, gene identification searches, and in the analysis of multiple regions of similarity in long DXA sequences. In addition, to its flexibility and tractabi1ity to mathematical analysis, BLAST is an order of magnitude faster than existing sequence comparison tools of comparable sensitivity.
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