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The Relationship between Hemoglobin A1c and Major Adverse Cardiac Events in Nondiabetic Acute Myocardial Infarction Patients Underwent Primary Percutaneous Coronary Intervention

The Relationship between Hemoglobin A1c and Major Adverse Cardiac Events in Nondiabetic Acute Myocardial Infarction Patients Underwent Primary Percuta

The Relationship between Hemoglobin A1c and Major Adverse Cardiac Events in Nondiabetic Acute Myocardial Infarction Patients Underwent Primary Percutaneous Coronary Intervention  
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Yeon Sang Lee, Myung Ho Jeong, Kye Hun Kim, Dong Goo Kang, Kyung Ho Yun, Sang Hyun Lee, Sang Yup Lim, Seo Na Hong, Hyung Wook Park, Young Joon Hong, Ju Han Kim, Weon Kimhttp://academic.research.microsoft.com/io.ashx?type=5&id=13642078&selfId1=0&selfId2=0&maxNumber=12&query=
Background and Objectives:Hyperglycemia on hospital admission is a known important risk factor in patients with acute myocardial infarction. The purpose of this study was to investigate the relation between the level of he- moglobin A1c (HbA1c) and major adverse cardiac events (MACE) in non-diabetic acute myocardial infarction patients who underwent primary percutaneous coronary intervention (PCI). Subjects and Methods:Of the 105 acute myocardial infarction patients who underwent primary PCI between January 2002 and December 2002, 68 non diabetic patients were analyzed. The patients were divided into two groups: group I (n=46, 58.7±12.5 years, 37 male) with low levels of HbA1c (<6%) and group II (n=22, 64.6±13.1 years, 18 male) with elevated levels of HbA1c (6% to 7%). MACE was observed during the six-month clinical follow-up. Results:There were no dif- ferences in the risk factors for atherosclerosis and angiographic characteristics between the two groups. Group II had a significantly higher rate of MACE (13% vs. 36%, p=0.026) compared to Group I. Logistic regression analysis disclosed that an elevated level of HbA1c, between 6 and 7%, was a significant independent predictor of MACE. Conclusion:An elevated level of HbA1c is a significant prognostic factor in non-diabetic acute myocardial infarc- tion patients after primary PCI. (Korean Circulation J 2005;35:369-374)
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