Lymphoepithelioid Lymphoma (Lennert's Lymphoma) Is a Monoclonal Proliferation of Helper/Inducer T Cells

Lymphoepithelioid Lymphoma (Lennert's Lymphoma) Is a Monoclonal Proliferation of Helper/Inducer T Cells,A. C. Feller,G. H. Griesser,T. W. Mak,K. Lenne

Lymphoepithelioid Lymphoma (Lennert's Lymphoma) Is a Monoclonal Proliferation of Helper/Inducer T Cells   (Citations: 13)
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Lymphoepithelioid lymphoma (Lennert's lymphoma) was first described as a special variant of Hodgkin's disease. This lesion is characterized by a high percentage of epithe- lioid and T cells and rarely contains the classical Hodgkin's/ Reed-Sternberg cells. Cytogenetic abnormalities indicate that Lennert's lymphoma is of T cell origin. In the present study. immunohistochemical investigation of four cases of Lennerts lymphoma revealed two major cell populations of T cells that predominantly express the helper-inducer phenotypeand Ki-M6- and Ki-M8-positive macrophages and epithelioid cells. Double-staining experiments for the A LTHOUGH THE MAJORITY of malignant lympho- mas can be classified as being derived from either the T or B cell lineage, the lineage of certain lesions such as Hodgkin's disease, lymphoepithelioid lymphoma (Lennert's lymphoma), and lymphogranulomatosis X/angioimmuno- blastic lymphadenopathy is uncertain. Lymphoepithelioid lymphoma (LEL) was first described by Lennert' and later by Lennert and Mestdagh2 as a special variant of Hodgkin's disease characterized by a high percentage of epithelioid cells and rarely containing the Reed-Sternberg cells charac- teristic of classical Hodgkin's disease. This disease was called Lennert's lymphoma by Dorfman and Warnke3 and Lukes and Tindle,4 and as a result of findings that pointed to a T cell origin for the diseases, the term was changed from lympho- epithelioid cellular lymphogranulomatosis to lymphoepithe- lioid cell lymphoma. Although cytogenetic studies show chromosomal abnormalities that are in accordance with the designation of a T cell-derived malignant lymphoma and immunohistochemical investigations show a high percentage of T cells�7 in this lymphoma, it is not known whether they represent the clonal population responsible for neoplastic proliferation. In this study, we report the results of immuno- histochemical analysis of LEL, using double staining with conjugated monoclonal antibodies in an effort to identify the cell surface phenotype of the proliferating neoplastic cell. We have also characterized T cell receptor fl-chain and immuno- globulin heavy-chain gene rearrangements in these cells to substantiate the immunohistochemical findings. Our results strongly support the hypothesis that LEL is a T cell lympho- ma, probably of the T helper/inducer class. detection of cell surface antigens and the proliferation- associated antigen Ki67 showed that only the CD4-positive cells (helper-inducer T cells) were proliferating. Examina- tion of the DNA of these Lennert's lymphoma samples also indicated that monoclonal rearrangement of the T cell receptor /3-chain genes has occurred. whereas the immu- noglobulin heavy- and ic-chain genes remained in germline configuration. Our results strongly suggest that Lennerts lymphoma is a CD4-positive T cell lymphoma.
Published in 1986.
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