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Evolution by gene duplication

Evolution by gene duplication,S. Ohno

Evolution by gene duplication   (Citations: 1965)
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Published in 1970.
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    • ...A similar architecture is maintained in zebrafish (chromosome 10) and in medaka (chromosome 14). A complementary search for fish marker genes throughout the known mammalian genomes showed that AKT2 encodes for a kinase: RAC-beta serine/threonine-protein kinase. We found two copies of this gene in fishes: AKT2a and AKT2b. The AKT2a gene is found close to the cluster of genes that, in mammals, flank OVOL3, suggesting that OVOL3b in fishes is a paralog of OVOL3, developed by duplication of the OVOL3 locus. Subsequently, fishes lost OVOL3 in the original locus and the duplicated gene (OVOL3b) was retained at the duplicated locus. We found the cluster of genes that identify the duplicated OVOL3b gene at the duplicated loci in three fish genomes: fugu, zebrafish and in medaka. These fish genomes did not retain the original OVOL3 gene, offering rudimentary evidence of fish-specific whole-genome duplication events ...

    Abhishek Kumaret al. Molecular Phylogeny of OVOL Genes Illustrates a Conserved C2H2 Zinc Fi...

    • ...One mechanism by which PPI networks change is gene duplication (DU) ...

    G. Jack Petersonet al. Simulated Evolution of Protein-Protein Interaction Networks with Reali...

    • ...Based on evidences such as genome sizes and allozymes, Susumu Ohno suggested that the genomes of early vertebrates have been formed by two whole genome duplications (WGDs) ...

    Mi Zhouet al. Comparative and Evolutionary Analysis of the HES/HEY Gene Family Revea...

    • ...

      How complexity and novel functions evolve has been a longstanding question in evolutionary biolog...

    Gregory C. Finniganet al. Evolution of increased complexity in a molecular machine

    • ...Important evolutionary transitions and adaptive radiations, such as the origin and diversification of land plants, have been associated with gene family expansions resulting from large-scale gene duplication or whole-genome duplication events (Ohno, 1970; De Bodt et al...

    Frederik Leliaertet al. Phylogeny and Molecular Evolution of the Green Algae

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