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Estabilidad del acetato de hidrocortisona en formulaciones en forma de crema al 1% Hydrocortisone acetate stability in 1% cream formulations

Estabilidad del acetato de hidrocortisona en formulaciones en forma de crema al 1% Hydrocortisone acetate stability in 1% cream formulations,Comunicac

Estabilidad del acetato de hidrocortisona en formulaciones en forma de crema al 1% Hydrocortisone acetate stability in 1% cream formulations  
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RESUMEN: soluciones alcohólicas, hidroalcohólicas y cremas de acetato de hidrocortisona (HCAc) al 1% se sometieron a con- diciones degradativas: medio ácido (HCl 1 M), medio alcalino (NaOH 0,1M) y condiciones oxidantes (H 2 O 2 3%) por periodos variables de tiempo y temperatura. Los productos de degradación se detectaron mediante técnicas de HPLC (CLAR). Los re- sultados obtenidos permiten valorar la estabilidad del HCAc y su crema al 1%. Se propone un mecanismo de degradación de este principio activo en sus formulaciones. ABSTRACT: Alcoholics, aquoethanolic and 1% creams of hydrocortisone acetate (HCAc) were treated under degradative condi- tions: acid environment (HCl 1 M), alkaline (NaOH 0,1M) and oxidative conditions (H 2 O 2 3%) during several periods of time and temperature. The degradation products were detected by HPLC (CLAR). The obtained results allow to evaluate the stability of the HCAc and its 1% cream. A mechanism of degradation of this active principle in its formulations is proposed.
Published in 2007.
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