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Metabolism of Aflatoxin in Sheep: Excretion of the `Milk Toxin'

Metabolism of Aflatoxin in Sheep: Excretion of the `Milk Toxin',10.1038/209154a0,Nature,R. Allcroft,H. Rogers,G. Lewis,J. NABNEY,P. E. BEST

Metabolism of Aflatoxin in Sheep: Excretion of the `Milk Toxin'   (Citations: 26)
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Journal: Nature , vol. 209, no. 5019, pp. 154-155, 1966
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    • ...Aflatoxin B-1 was detected in milk which is the popular food stuff for human beings (3)...

    M. A. Mohranet al. Effect of aflatoxin B1 on the proteolytic activity of some lactic-acid...

    • ...Allcroft et al. (2) suggested the trivial name aflatoxin M which indicates the original derivation from milk because the authors identified this metabolite in the liver, kidney and urine as well as in the milk of animals that ingested aflatoxins B~ and G~. Butler and Clifford (4) have previously postulated that the adsorbed aflatoxin B l from gut appears in the liver and apparently undergoes in part (1-3% has been determined after that in ...
    • ...The developed spots were matched with authentic samples of B l and G1 (2)...
    • ...Figures 1 and 4 show that both the aflatoxin and the metabolite in each case is excreted in the urine within the period of 6 h in vitro metabolism (2)...
    • ...3 & 6). This supports the metabolic function of liver (9, 10, 11, 12) and kidney (2)...

    A. Y. Nassaret al. Binding of aflatoxin B 1 , G 1 and M to plasma albumin

    • ...The sheep are resistant (32, 38) to AFBI hepatocarcinogenic effect and acute toxicity...

    C. L. Mendenhallet al. Peliosis hepatis

    • ...These hydroxylated aflatoxins were also isolated from lactating rats (10, 11), rat liver (7), and from cow and sheep faeces and urine (4, 5, 18, 19, 21)...

    E. B. Lillehojet al. Aflatoxin M 1 removal from aqueous solutions by Flavobacterium auranti...

    • ...Aflatoxin BI is converted in the liver of a number of species, including rats, to its hydroxylated derivative aflatoxin M! , which is found in the blood and urine of rats and in the milk of lactating rats, sheep, and cattle (3, 5, 8, 9, 10)...

    H. C. Griceet al. The Carcinogenic Potential of Aflatoxin or Its Metabolites in Rats fro...

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