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Female Oxytocin-Deficient Mice Display Enhanced Anxiety-Related Behavior

Female Oxytocin-Deficient Mice Display Enhanced Anxiety-Related Behavior,10.1210/en.2002-0197,Endocrinology,ROSE C. MANTELLA,REGIS R. VOLLMER,XIA LI,J

Female Oxytocin-Deficient Mice Display Enhanced Anxiety-Related Behavior   (Citations: 49)
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Previous studies have suggested that oxytocin (OT) may be anxiolytic in female laboratory rats and mice. The elevated plus-maze was used to compare anxiety-related behaviors of OT-deficient (OT/) and wild-type (OT/) mice. Female OT/ mice displayed increased anxiety-related behavior compared with OT/ mice. The percentage of entries (P < 0.0002) and time spent (P < 0.003) in the open arms was less in female OT/ than OT/ mice. Administration of synthetic OT, 2 ng by intracerebroventricular (icv) injection to female OT/ mice, increased the percentage of entries (P < 0.003) and time spent (P < 0.004) in the open arms compared with artificial cerebrospinal fluid female OT/ mice. Administra- tion of an OT receptor antagonist (Atosiban, d(Dtyr(Et)2, Thr4)ornithine vasotocin) 100 ng icv, to female OT/ mice increased anxiety-related behavior by decreasing the per- centage of entries (P < 0.01) and time spent (P < 0.04) in the open arms compared with artificial cerebrospinal fluid- treated controls. Central infusion of an OT receptor antago- nist, 100 ng icv, before administration of synthetic OT, 2 ng icv, in female OT/ mice blocked the anxiolytic affect of OT. In contrast, male OT/ mice displayed decreased anxiety-re- lated behavior compared with male OT/ mice. The percent- age of entries (P < 0.007) and time spent (P < 0.004) in the open arms was greater in male OT/ vs. OT/ mice. Our findings indicate that OT pathways play a role in modulating anxiety in female mice of the C57BL/6 background, and the effect is mediated by the OT receptor. (Endocrinology 144: 2291-2296, 2003)
Journal: Endocrinology , vol. 144, no. 6, pp. 2291-2296, 2003
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