Academic
Publications
Ionic Wave Propagation along Actin Filaments

Ionic Wave Propagation along Actin Filaments,10.1016/S0006-3495(04)74255-1,Biophysical Journal,J. A. Tuszyński,S. Portet,J. M. Dixon,C. Luxford,H. F.

Ionic Wave Propagation along Actin Filaments   (Citations: 9)
BibTex | RIS | RefWorks Download
We investigate the conditions enabling actin filaments to act as electrical transmission lines for ion flows along their lengths. We propose a model in which each actin monomer is an electric element with a capacitive, inductive, and resistive property due to the molecular structure of the actin filament and viscosity of the solution. Based on Kirchhoff's laws taken in the continuum limit, a nonlinear partial differential equation is derived for the propagation of ionic waves. We solve this equation in two different regimes. In the first, the maximum propagation velocity wave is found in terms of Jacobi elliptic functions. In the general case, we analyze the equation in terms of Fisher-Kolmogoroff modes with both localized and extended wave characteristics. We propose a new signaling mechanism in the cell, especially in neurons.
Journal: Biophysical Journal - BIOPHYS J , vol. 86, no. 4, pp. 1890-1903, 2004
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...It is because actin filaments are polyelectrolytes surrounded by counterions that they possess the capacity of transmitting signals or sustaining ionic conductances [52, 53]...
    • ...Actin filaments have a linear charge density of 1.65 × 10 2 e/nm, which allows them to carry electric charge in the form of ionic flow along the longitudinal axis of the filament [53]...
    • ...As illustrated in Fig. 2, because of shielding, ions are able to travel along actin filaments without significantly affected by the surrounding environment [53]...
    • ...Fig. 2 Actin filaments support a traveling ionic cloud which is affected by the dipole moments of monomers (based on [53]) 10 A. Priel et al...
    • ...The mathematical similarity between this equation and the one obtained for the actin case [53] implies the possibility of a solitary wave solution...
    • ...• Each of the network’s elements (e.g., actin filaments and microtubules) behaves as a nonlinear electrical component [53, 75, 83]...

    Avner Prielet al. Neural cytoskeleton capabilities for learning and memory

    • ...The idea to examine MTs in the context of polyelectrolyte features was inspired by the experimental and theoretical results obtained earlier for actin filaments (Lin and Cantiello 1993; Tuszynski et al. 2004)...
    • ...We will follow the same theoretical approach first outlined in Tuszynski et al. (2004) for actin filaments, but it will be applied to MTs with special attention placed on their specific structural features...
    • ...The above derivation closely parallels an analogous derivation for actin filaments whose details can be found in Tuszynski et al. (2004)...

    M. V. Satarićet al. A nonlinear model of ionic wave propagation along microtubules

    • ...An electrical amplifier by a cytoskeletal biopolymer such as the MT provides a relevant and important key component to an electrodynamic network in conjunction with electrical coupling by current generators (i.e., MT-regulated channels (5)), and MT-coupled intracellular transmission lines (F-actin) (14,15)...
    • ...Thus, we envision a mechanism in which, MT-ion channel interactions may regulate synaptic plasticity by the MT's ability to allow spatially oriented intracellular electrical signals in connection with actin filaments, also able to transmit electrical information (14,15)...

    Avner Prielet al. A Biopolymer Transistor: Electrical Amplification by Microtubules

    • ...Traveling waves have been calculated for both microtubules and actin filaments (Tuszynski et al., 1998, 2004)...

    Nancy J. Woolf. Acetylcholine, cognition, and consciousness

Sort by: