Academic
Publications
Inhibitory effect of nitric oxide on dopamine transporters: interneuronal communication without receptors

Inhibitory effect of nitric oxide on dopamine transporters: interneuronal communication without receptors,10.1016/j.neuint.2003.11.004,Neurochemistry

Inhibitory effect of nitric oxide on dopamine transporters: interneuronal communication without receptors   (Citations: 39)
BibTex | RIS | RefWorks Download
Previously we observed that Nω-nitro-l-arginine methyl ester (l-NAME) decreased the striatal dopamine (DA) release in microdialysis experiments and this effect was completely diminished in the presence of the DA uptake inhibitor nomifensine, indicating that the effect was mediated via the DA transporter. The aim of the present work was to study the direct effect of nitrergic compounds on DA uptake. We measured the uptake of [3H]DA in striatal slices and found that the nitric oxide (NO) generator sodium nitroprussid (100μM) decreased the uptake by 66%. In contrast, the NO synthase inhibitor l-NAME (100μM) increased the DA uptake by 80%, while the inactive d-NAME had no effect on uptake. Our data indicate that NO exerts an inhibitory effect on DA transporters. Since the production of NO by neuronal NO synthase is closely related to the activation of NMDA receptors, the level of NO around synapses reflects the activity of glutamatergic neurotransmission. The strength of excitatory input, therefore, can be nonsynaptically signaled by NO to the surrounding dopaminergic neurons via the inhibitory tone on transporters. The concomitant elevation of DA concentration around the activated synapse represents the response of dopaminergic system, which can adapt to the changing excitatory activity without receiving glutamatergic input and without expressing glutamate receptors. Thus, the effect of NO on transporters represents a new form of interneuronal communication, a nonsynaptic interaction without receptors.
Journal: Neurochemistry International - NEUROCHEM INT , vol. 45, no. 4, pp. 485-489, 2004
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...Besides modulating the glutamatergic system in a negative feedback manner, NO also interacts with serotonergic (Chanrion et al. 2007; Wegener et al. 2000), dopaminergic (Wegener et al. 2000; Kiss et al. 2004; Volz and Schenk 2004) and cholinergic systems (reviewed by de Vente 2004)...

    Kariina Laaset al. The effect of a functional NOS1 promoter polymorphism on impulsivity i...

    • ...Whether the effect is due to NO-induced depolarisation of intermediate neurons or to direct NO influence on the proteins associated with neurotransmitter release or uptake (Jansson et al. 1999; Kiss et al. 2004) remains to be elucidated...

    Varvara E. Dyakonovaet al. Coordination of rhythm-generating units via NO and extrasynaptic neuro...

    • ...[11, 12], mitochondrial respiration [13, 14], and endothelial function [10, 15‐19], among others...

    Carlos A. Marraet al. Lipid Metabolism in Rats is Modified by Nitric Oxide Availability Thro...

    • ...It has been observed that dopaminergic neurotransmission is influencedbyNObothinvitro(Hanbaueretal.,1992;Kiss,2000; Kiss et al., 2004; Lonart et al., 1993; Zhu and Luo, 1992 )a ndin vivo experiments (Iravani et al., 1998; Kiss et al., 1999; Lorrain and Hull, 1993; Strasser et al., 1994; West and Galloway, 1996)...
    • ...Because the participation of NMDA receptors on dopamine release induced by anatoxin-a found in this study, and since nNOS produces NO primarily in response to activation of NMDA (Brenman and Bredt, 1997; Garthwaite and Boulton, 1995; Kiss, 2000; Kiss et al., 2004; Schuman and Madison, 1994), we tested if NO could have some role on the effect of anatoxin-a...
    • ...The mechanism that determines that NO increases the striatal dopamine levels is not very clear, although same authors suggest that the possible mechanism through the NO enhances dopamine release is mediated by a reduction of transporter activity, increasing the concentration of dopamine in the extracellular medium (Kiss et al., 1999, 2004; Lonart and Johnson, 1994; Pogun et al., 1994)...
    • ...This effect of NO on transporters, could also represent a new way of interneuronal communication with non-synaptic interaction without receptors (Kiss et al., 2004)...

    Francisco Camposet al. Mediation of glutamatergic receptors and nitric oxide on striatal dopa...

    • ...This agrees with several studies showing that NO increases DA release (West and Galloway 1997; Zhu and Luo 1992) and inhibits its re-uptake, while NOS inhibitors increase DA uptake (Kiss et al. 1999, 2004)...

    C. Salumet al. Dopamine and nitric oxide interaction on the modulation of prepulse in...

Sort by: