Obstacles facing translational research in academic medical centers

Obstacles facing translational research in academic medical centers,10.1096/fj.01-0540lsf,Faseb Journal,JORDAN S. POBER,CRYSTAL S. NEUHAUSER,JEREMY M.

Obstacles facing translational research in academic medical centers   (Citations: 36)
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Over the last quarter of the 20th century, there has been a boom in biomedical research discov- eries that, for the most part, has not been successfully exploited for improving medical therapy or diagnosis. This lack of success is surprising because there is a broad consensus within academic medical centers (AMCs) that a primary mission is to move scientific discoveries into meaningful clinical outcomes, and there are numerous opportunities for doing so. We illustrate the latter point with 10 clinical opportunities for translating scientific discoveries from our field of vascular biology and transplantation. We attribute the limited success of translation to various factors, chief of which is that translation is rarely straightforward and requires continuing research in both the clinic and the laboratory. Translational research is hindered by insuf- ficient targeted resources, a shortage of qualified inves- tigators, an academic culture that hinders collaboration between clinical and laboratory-based investigators, a traditional structure of the AMC that favors departmen- tal efforts over interdisciplinary programs, an increas- ing regulatory burden, and a lack of specific mecha- nisms within the AMC for facilitating solutions to these problems. We offer several suggestions to reduce these impediments.—Pober, J. S., Neuhauser, C. S., Pober, J. M. Obstacles facing translational research in aca- demic medical centers. FASEB J. 15, 2303-2313 (2001)
Journal: Faseb Journal - FASEB J , vol. 15, no. 13, pp. 2303-2313, 2001
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