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Automatic CT-ultrasound registration for diagnostic imaging and image-guided intervention

Automatic CT-ultrasound registration for diagnostic imaging and image-guided intervention,10.1016/j.media.2008.06.006,Medical Image Analysis,Wolfgang

Automatic CT-ultrasound registration for diagnostic imaging and image-guided intervention   (Citations: 33)
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The fusion of tracked ultrasound with CT has benefits for a variety of clinical applications, however exten- sive manual effort is usually required for correct registration. We developed new methods that allow one to simulate medical ultrasound from CT in real-time, reproducing the majority of ultrasonic imaging effects. They are combined with a robust similarity measure that assesses the correlation of a combina- tion of signals extracted from CT with ultrasound, without knowing the influence of each signal. This serves as the foundation of a fully automatic registration, that aligns a D ultrasound sweep with the cor- responding tomographic modality using a rigid or an affine transformation model, without any manual interaction. These techniques were evaluated in a study involving 25 patients with indeterminate lesions in liver and kidney. The clinical setup, acquisition and registration workflow is described, along with the evalu- ation of the registration accuracy with respect to physician-defined Ground Truth. Our new algorithm correctly registers without any manual interaction in 76% of the cases, the average RMS TRE over multiple target lesions throughout the liver is 8.1 mm.
Journal: Medical Image Analysis - MED IMAGE ANAL , vol. 12, no. 5, pp. 577-585, 2008
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