Meta-analysis of residential exposure to radon gas and lung cancer

Meta-analysis of residential exposure to radon gas and lung cancer,Maria Pavia,Aida Bianco,Claudia Pileggi,Italo F. Angelillo

Meta-analysis of residential exposure to radon gas and lung cancer   (Citations: 14)
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Objectives To investigate the relation between residential exposure to radon and lung cancer. Methods A literature search was performed using Medline and other sources. The quality of studies was assessed. Adjusted odds ratios with 95% confidence intervals (CI) for the risk of lung cancer among categories of levels of exposure to radon were extracted. For each study, a weighted log-linear regression analysis of the adjusted odds ratios was performed according to radon concentration. The random effect model was used to combine values from single studies. Separate meta-analyses were performed on results from studies grouped with similar characteristics or with quality scores above or equal to the median. Findings Seventeen case-control studies were included in the meta-analysis. Quality scoring for individual studies ranged from 0.45 to 0.77 (median, 0.64). Meta-analysis based on exposure at 150 Bq/m3 gave a pooled odds ratio estimate of 1.24 (95% CI, 1.11-1.38), which indicated a potential effect of residential exposure to radon on the risk of lung cancer. Pooled estimates of fitted odds ratios at several levels of radon exposure were all significantly different from unity — ranging from 1.07 at 50 Bq/m3 to 1.43 at 250 Bq/m3. No remarkable differences from the baseline analysis were found for odds ratios from sensitivity analyses of studies in which >75% of eligible cases were recruited (1.12, 1.00-1.25) and studies that included only women (1.29, 1.04-1.60). Conclusion Although no definitive conclusions may be drawn, our results suggest a dose-response relation between residential exposure to radon and the risk of lung cancer. They support the need to develop strategies to reduce human exposure to radon.
Published in 2003.
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    • ...Indoor air radon levels vary widely in homes and other buildings. Average cumulative radon doses from lifetime residential exposures are about 10-fold lower than those among exposed miners. Despite the relatively low average radon levels in homes, combined analysis of 17 epidemiologic studies showed that persons with time-weighted average residential radon exposures of 150 Bq/m3 (the current level above which the Environmental Protection Agency recommends actions to confirm radon levels and sources and the need for remedial measures such as ventilation) had a 24% (95% CI 11%–38%) increased lung cancer risk [...

    Donald T. Wigleet al. Human Health Risks from Low-Level Environmental Exposures: No Apparent...

    • ...Two recent studies, which include data on individuals’ smoking habits, have shown an association between exposure to radon in homes and lung cancer (12,13)...

    A. Astbury. Cancer mortality in the USA and cosmic ray neutron dosage

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