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Proteína C reactiva de alta afinidad como marcador inflamatorio

Proteína C reactiva de alta afinidad como marcador inflamatorio,Carlos Ramírez Velázquez,Gustavo Martínez Juárez,Juan Lozano Nuevo,Arturo Olvera,Lourd

Proteína C reactiva de alta afinidad como marcador inflamatorio   (Citations: 1)
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0.014 a 3.9 mg/L, 4.0 a 7.9 mg/L, 8.0 a 11.9 mg/L, 12 a 14.9 mg/L y 15 mg/L o más. Los de AI fueron 16 (64%), 2 (8%), 0 (0%), 5 (20%) y 2 (8%), respectivamente. Los de IAM, 15 (60%), 3 (12%), 4 (16%), 3 (12%) y 0 (0%), respectivamente. Para ninguna prueba estadística hubo diferencia significativa (p >0.05). Conclusiones: las concentraciones séricas de PCR medidas con técnica de alta afinidad son un parámetro muy importante en la detección temprana de los procesos inflamatorios, tanto en enfermedades inmunológicas como no inmunológicas. Palabras clave: proteína C reactiva, angina inestable, infarto agudo de miocardio. ABSTRACT Antecedents: Non-immunological and immunological diseases have been reported to present a level of serum C-reactive protein (CRP) higher than the base level. For both, this level can guide the diagnosis and prognosis. Objective: To test the value of serum CRP, by a high-sensitivity CRP assay, during a non-immunological disease, in order to unders- tand if this level is significant during the non-immunological diseases. Patients and methods: In this study, 50 patients were divided in two groups according to different specific illness: 25 patients with unstable angina (UA) and 25 with acute myocardial infarction (AMI) with and without metabolic syndrome associated. Plasmatic CRP measurement was made for every patient, following an immunoturbidimetric high affinity technique performed in a RX Daytona TM clinical chemistry analyzer by Randox®. Statistical comparison of the serum CRP level between groups was done using a Student's t-test. An ANOVA test was used to value cardiovascular risk factors associated with the serum CRP level. A p < 0.05 was considered to be significant. Results: To each illness, patients were classified into five subgroups, based on their plasmatic CRP level: 0.014 to 3.9 mg/L, 4 to 7.9 mg/L, 8.0 to 11.9 mg/L, 12 to 14.9 mg/L, and higher than 15 mg/L. Patients with UA were 16 (64%), 2 (8%), 0 (0%), 5 (20%), and 2 (8%), respectively. And patients with AMI were 15 (60%), 3 (12%), 4 (16%), 3 (12%), and 0 (0%), respectively. Statistical tests performed did not have significant difference. Conclusions: We have proved that the serum CRP level, determined by a high-sensitivity CRP assay, can be useful in early detection
Published in 2007.
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