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Quantification of F-18 FDG PET Images in Temporal Lobe Epilepsy Patients Using Probabilistic Brain Atlas

Quantification of F-18 FDG PET Images in Temporal Lobe Epilepsy Patients Using Probabilistic Brain Atlas,10.1006/nimg.2001.0783,Neuroimage,Keon Wook K

Quantification of F-18 FDG PET Images in Temporal Lobe Epilepsy Patients Using Probabilistic Brain Atlas   (Citations: 32)
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A probabilistic atlas of the human brain (Statistical Probabilistic Anatomical Maps: SPAM) was developed by the international consortium for brain mapping (ICBM). It is a good frame for calculating volume of interest (VOI) in many fields of brain images. After calculating the counts in VOI using the product of probability of SPAM images and counts in FDG images, asymmetric indices (AI) were calculated and used for finding epileptogenic zones in mesial temporal lobe epilepsy (mTLE). FDG PET images from 18 surgically confirmed mTLE patients and 22 age-matched controls were spatially normalized to the average brain MRI template of ICBM. Counts from normalized PET images were multiplied with the probability of 12 VOIs from SPAM images in both temporal lobes. Finally AI were calculatedon each pair of VOIs, and compared with visualassessment. If AI of mTLE patients were notwithin 2.9 standard deviation from those of normalcontrol group (P < 0.008; Bonferroni correction for P < 0.05), epileptogenic zones were consideredto be found successfully. The counts of VOIs in the normal control group were symmetric (AI < 4.3%, paired t test P > 0.05) except for those of theinferior temporal gyrus (P < 0.001). By AIs in six pairs of VOIs, PET in mTLE had deficit on one side (P < 0.05). Lateralization was correct in only 14/18 of patients by AI, but 17/18 were consistent with visual inspection. In three patients with normal AI, PET images were symmetric on visual inspection. The asymmetric indices obtained by taking the product of the statistical probability anatomical map and FDG PET, correlated well with visual assessment in mTLE patients. SPAM is useful for the quantification of VOIs in functional images.
Journal: Neuroimage , vol. 14, no. 1, pp. 1-6, 2001
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    • ...The probabilistic maps could also be utilized as the standardized volume of interest (VOI) (or region of interest, ROI) to estimate the regional intensity of the brain image data [6] (Fig. 2)...
    • ...To overcome these problems, delineation of the VOI definition in 3D space has to be automated with high accuracy and reproducibility [6-8]...
    • ...MNI SPAM was first applied to obtain the normal range and the distribution of glucose uptake on F-18 fluorodeoxyglucose (FDG) PET [6]...

    Jae Sung Leeet al. Analysis of Functional Brain Images Using Population-Based Probabilist...

    • ...The regional uptake of radiotracers in PET and in single photon emission computed tomographic (SPECT) images can be quantified by averaging regional intensities, which are weighted using the probabilistic maps of certain brain regions after they have been spatially normalized into the standardized coordinates (Kang et al., 2001)...

    Jae Sung Leeet al. Probabilistic map of blood flow distribution in the brain from the int...

    • ...To define the activity map, a theoretical model of brain perfusion was established from real SPECT data using an anatomical standardization method (see figure 1). Similar approaches using anatomically standardized VOIs to perform measurements were previously described (e.g., Koyama et al 1997, Lobaugh et al 2000, Van Laere et al 2001, Kang et al 2001, Pagani et al 2002)...
    • ...inter-individual analysis of brain function has been underlined previously (Lobaugh et al 2000, Van Laere et al 2001, Kang et al 2001)...
    • ...the temporal lobe was based on electrophysiological criteria (Bartolomei et al 1999) and differed from other spatial models deduced from sulco-gyral morphology (Lobaugh et al 2000, Kang et al 2001)...

    C. Grovaet al. A methodology for generating normal and pathological brain perfusion S...

    • ...In comparison with typical ROI or VOI based methods, our method avoids the problem of anatomical region delineation (Kang et al 2001)...
    • ...In comparison with these approaches, the proposed method avoids the problem of delineating anatomical regions, which depends on the clinical context (Kang et al 2001)...

    Bérengère Aubert-brocheet al. Detection of Inter-hemispheric Asymmetries of Brain Perfusion in SPECT

    • ...The counts from count- and spatially normalized PET images were multiplied by the probability from 98 VOIs of the Statistical Probabilistic Anatomical Map (SPAM) of the International Consortium for Brain Mapping and the probability-weighted counts were obtained objectively for all VOIs (21,22)...

    Yu Kyeong Kimet al. Differential Features of Metabolic Abnormalities Between Medial and La...

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