The Determinant Factors of Recurrence Following Resection for Ductal Pancreatic Cancer

The Determinant Factors of Recurrence Following Resection for Ductal Pancreatic Cancer,Giuliano Barugola,Massimo Falconi,Rossella Bettini,Letizia Boni

The Determinant Factors of Recurrence Following Resection for Ductal Pancreatic Cancer   (Citations: 9)
BibTex | RIS | RefWorks Download
Summary Long-term survival for patients with pancreatic carcinoma is low, even following resection. Most patients who undergo curative treatment, develop recurrence usually at the same site of resection or in the liver. Failure seals the fate of the patient. Local recurrence occurs frequently; however, it is rarely a direct cause of death. In fact, most patients die from distant metastases. From a clinical point of view, it is important to distinguish recurrence from relapse. In fact, recurrence can be recognized as the reappearance of the disease in the surgical bed, often due to inadequate surgical clearance. On the other hand, the concept of relapse should be much more related to the appearance of the disease in a distant site. Both underestimated staging of the diagnosis and the biological features of the tumor can cause relapse. Up to now, there have only been a few reviews on the incidence and pattern of failure following resection. Detailed knowledge of the recurring sites of pancreatic carcinoma and study of the factors influencing disease- free survival are significant in developing neoadjuvant, surgical and adjuvant treatment. The aim of this review is to point out the major factors most commonly identified as determinants of both recurrence and relapse.
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...In terms of recurrence after R0 resection, overall recurrence rates were in accordance with the literature [14, 15]...
    • ...In the present study, unlike that reported previously [15, 18, 20], overall and disease-free survivals were significantly higher after R0 than R1 resection, which emphasizes the importance of local clearance during surgery...

    Mee Joo Kanget al. Comparison of the long-term outcomes of uncinate process cancer and no...

    • ...Ninety-five percent of tumors relapse within 2 years from their resection, and the most common sites of failure (97%) are intra-abdominal [17]...
    • ...There is, in fact, an opposite correlation between the morbidity and the mortality observed, especially after pancreaticoduodenectomy, and the number of patients resected per year [17]...

    Giuliano Barugolaet al. Cancer of the Exocrine Pancreas: Surgery and Multimodal Treatment

Sort by: