Academic
Publications
Tumor M2Pyruvate Kinase in Patients Suffering from Pancreatic Cancer

Tumor M2Pyruvate Kinase in Patients Suffering from Pancreatic Cancer,E. Coato,L. Frulloni,S. Carrara,S. Brunelli,B. Ferri,B. Calore,L. Bernardoni,K. F

Tumor M2Pyruvate Kinase in Patients Suffering from Pancreatic Cancer  
BibTex | RIS | RefWorks Download
Background: Tumour marker pyruvate kinase type tumour M2 has been proposed as a new specific marker for the diagnosis of pancreatic cancer. Aim of the study was to evaluate M2-PK in patients with benign, malignant and metastasic pancreatic lesions and to compare it to the reference marker Ca 19-9. Materials and Methods: We studied 54 healthy volunteers and 103 consecutive patients suffering from pancreatic diseases (49 females, 54 males; mean age 56 13 years): 57 patients from pancreatic cancer (50 adenocarcinoma, 7 intraductal mucin-producing tumour, all histological documented), 30 from chronic pancreatitis and 16 from acute recurrent pancreatitis. Blood samples were evaluated for M2-PK by a commercial Elisa kitt (Schebo Biotech, Glessen, Germania) and for Ca 19-9 (Byk Gulden, Milano, Italia). Results: The M2-PK plasma levels were higher than upper normal limit in 64% of patients with pancreatic cancer, 50% of patient with chronic pancreatitis, 31% of patient with acute recurrent pancreatitis, and in 20% of healthy volunteers (p 0.0001 chi- square test). The sensitivity of M2-PK in diagnosing pancreatic cancer was 64% and specificity 69%, lower than sensitivity and specificity of Ca 19-9, 72% and 94% respec- tively. Metastatic disease was correlated to a significant increment in plasma levels of M2-PK (p 0.001 metastatic disease vs. non metastatic disease), while no differences were found related to the presence of regional or vascular infiltration or tumour site. A contemporary elevation of the two tumour-related markers was more common in pancre- atic cancer (48%) compared to the other groups studied (p 0.0001). Conclusions: Our study shows that M2-PK has a lower sensitivity and specificity in diagnosing pancreatic cancer compared to Ca 19-9. However, in patients with adeno- carcinoma we observe frequently a simultaneous increase of M2-PK and Ca 19-9. In addition, M2-PK is more commonly elevated in metastatic disease and may be an addi- tional criterium to decide on radical surgery of pancreatic cancer.
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.