MicroRNAs,10.1016/S0092-8674(04)00045-5,Cell,David P. Bartel

MicroRNAs   (Citations: 1803)
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MicroRNAs (miRNAs) are endogenous ∼22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal: Cell , vol. 116, no. 2, pp. 281-297, 2004
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    • ...The processing of miRNA is well studied and is comprised of a discrete series of steps (1)...
    • ...miRNA genes are transcribed and excised into miRNAs, then miRNA is recruited by RISC (RNA-induced silencing complex, including Argonaute and other proteins) which combines with mRNA to inhibit or degrade the target mRNA (1) and thus translation is interrupted...

    Zhenhai Zhanget al. PMRD: plant microRNA database

    • ...Among the small regulatory RNAs, the miRNA family is the most extensively studied and their biogenesis and mechanisms of downregulating gene expression represent some of the most exciting and fascinating areas in molecular biology (1,2)...
    • ...MicroRNAs in RISC bind to\ the 30UTRs of transcripts harboring complementary ‘seed’ targets, ultimately resulting in translational repression (1,13) or in some cases degradation of the targeted mRNA in RNA processing bodies (P-bodies) (14,15)...

    Guihua Sunet al. Sequence context outside the target region influences the effectivenes...

    • ...The pre-miRNAs are then exported by Exportin 5 (Exp5) to the cytoplasm, where Dicer processing renders mature double-stranded miRNAs that interact with the RNAinduced silencing complex (RISC) (1,8,9)...

    Oscar Aparicioet al. Adenovirus VA RNA-derived miRNAs target cellular genes involved in cel...

    • ...In addition to regulation at the transcriptional level, it is increasingly recognized that an important fraction of regulation occurs posttranscriptionally, and to a large extent by microRNAs (miRNAs) (Lai 2003; Ambros 2004; Bartel 2004; Alvarez-Garcia and Miska 2005; Plasterk 2006; Chen and Rajewsky 2007)...
    • ...First, they are one of the most abundant classes of regulators, currently estimated to comprise 1%–5% of animal genes (Bartel 2004; Bentwich et al. 2005a; Berezikov et al. 2005)...

    Alexander Starket al. Systematic discovery and characterization of fly microRNAs using 12 Dr...

    • ...miRNAs are naturally occurring small, single-stranded, noncoding RNAs that mediate gene expression at the posttranscriptional and translational levels in both plants and animals (Ambros 2004; Bartel 2004)...

    YAGUANG XIet al. Systematic analysis of microRNA expression of RNA extracted from fresh...

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