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Glucocorticoids Decrease Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Paraventricular Nucleus of the Human Hypothalamus

Glucocorticoids Decrease Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Paraventricular Nucleus of the Human Hypothalamus,

Glucocorticoids Decrease Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Paraventricular Nucleus of the Human Hypothalamus   (Citations: 14)
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The way glucocorticoids affect TRH mRNA expression in the paraventricular nucleus of the hypothalamus is still unclear. In view of its relevance for Cushing's syndrome and depres- sion, we measured TRH mRNA expression in human hypo- thalami obtained at autopsy by means of quantitative TRH mRNA in situ hybridization. In corticosteroid-treated sub- jects (n 10), TRH mRNA hybridization signal was decreased as compared with matched control subjects (n 10) (Mann- Whitney U test, P 0.02). By inference, hypercortisolism as present in patients with Cushing's syndrome or major depres- sion may contribute to lower serum TSH or symptoms of de- pression by lowering hypothalamic TRH expression. (J Clin Endocrinol Metab 90: 323-327, 2005)
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