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Assessing antidepressant activity in rodents: recent developments and future needs

Assessing antidepressant activity in rodents: recent developments and future needs,10.1016/S0165-6147(02)02017-5,Trends in Pharmacological Sciences,Jo

Assessing antidepressant activity in rodents: recent developments and future needs   (Citations: 448)
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Animal models are indispensable tools in the search to identify new antidepressant drugs and to provide insights into the neuropathology that underlies the idiopathic disease state of depression. As new targets are developed, both serendipitously and through hypothesis-driven research, existing animal paradigms are being modified and new tests are being developed to detect antidepressant actions of compounds acting on a broad range of neural and genetic targets. This review focuses on recent findings regarding some of the most widely employed animal models used currently to predict antidepressant potential. Emphasis is placed on recent modifications to such paradigms that have increased their utility and reliability. Furthermore, some key issues that need to be addressed for future discovery of novel antidepressant agents are examined, and the available data on genetically altered mice that might lead to the discovery of novel targets for antidepressant action are collated.
Journal: Trends in Pharmacological Sciences - TRENDS PHARMACOL SCI , vol. 23, no. 5, pp. 238-245, 2002
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    • ...Increase in immobility is interpreted as a failure of persistence in escape-directed behavior (Cryan et al, 2002)...

    Ji-Eun Kimet al. Alcohol exposure induces depression-like behavior by decreasing hippoc...

    • ... One of the main issues will be the translating of data from pre-clinical models to the human situation, this is especially difficult with psychiatric conditions owing to the complex nature of these disorders, with many aspects being exclusive to the human condition...

    R M O'Connoret al. Little things on which happiness depends: microRNAs as novel therapeut...

    • ...Animal behavioral models in which chronic, but not short-term, antidepressant treatment alters behavior are critically needed for studying the mechanisms underlying the antidepressant response (Cryan et al. 2002; Dulawa and Hen 2005)...
    • ...Few animal models sensitive to chronic, but not short-term, antidepressant treatment exist that are reliable and easy to use (Berton and Nestler 2006; Cryan et al. 2002)...
    • ...FST studies using mice usually do not include a pretest (Bourin et al. 2005; Lucki et al. 2001; Porsolt et al. 1977), while rat FST studies have typically used a pretest 24 h before testing (Cryan et al. 2002; Porsolt et al. 1977; but see Cryan et al. 2005)...
    • ...It is widely thought that only one FST exposure is sufficient to generate an increased and stable immobility readout in mice (Cryan et al. 2002), making pretesting unnecessary...

    Jianwei Jiaoet al. Antidepressant response to chronic citalopram treatment in eight inbre...

    • ...Generally, antidepressants of distinct classes are able to reduce immobility time in mice and rats (Cryan et al. 2002)...

    Pedro R. T. Romãoet al. Anti-HIV Drugs Nevirapine and Efavirenz Affect Anxiety-Related Behavio...

    • ...The forced swimming test (FST) in male mice and rats is commonly used to screen antidepressant drugs; most antidepressant drugs used clinically shorten the duration of the immobility time (for reviews, see Bourin et al. 2001; Cryan et al. 2002)...
    • ...It has been considered that the duration of immobility in an inescapable situation, like the FST, closely correlates with a depressive-like state, and that virtually all antidepressants used clinically decreases immobility time in male mice (Cryan et al. 2002)...

    Noriko Yamadaet al. Identification of antidepressant-like ingredients in ginseng root ( Pa...

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