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Prostate-SpecificAntigen: Biochemistry,Analytical Methods,and Clinical Application

Prostate-SpecificAntigen: Biochemistry,Analytical Methods,and Clinical Application,David A. Armbruster

Prostate-SpecificAntigen: Biochemistry,Analytical Methods,and Clinical Application   (Citations: 29)
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greater clinical sensitivity eventhough it has less clinical specificity. PSA isuseful formonitoring therapy, particu- larly surgical prostatectomy, because complete removal oftheprostate gland should result in PSAbeing undetect- able.Measurable PSA after radical prostatectomy indi- cates residual prostatictissue or metastasis,and increas- ing PSAconcentrationsindicaterecurrentdisease. PSAis also useful forscreening selected populations of patients with symptoms indicative of prostate cancer; its use for general screening isdebatable becauseofits less-than- optimal specificity,thecostof unselected screening, and thelack of evidence that early detection of prostate cancer decreases morbidity and mortality. Distinguishing between patients with prostatic cancerandthosewith benignprostatic hypertrophy isparticularly difficult be- cause of the overlap in PSA values in the two groups. Determining the rate of change in PSA per year from serial measurementsor calculating the ratio of PSA per volumeoftheprostate glandmayallow these two groups to be more readily differentiated.
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