Academic
Publications
Oxidative stress parameters in rats exposed to fluoride and caffeine

Oxidative stress parameters in rats exposed to fluoride and caffeine,10.1016/j.fct.2010.03.033,Food and Chemical Toxicology,I. Inkielewicz-Stepniak,W.

Oxidative stress parameters in rats exposed to fluoride and caffeine   (Citations: 8)
BibTex | RIS | RefWorks Download
In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls drinking tap water; (II) controls drinking tap water and receiving intragastrically 0.5ml of tap water; (III) animals receiving 25mgF/L in drinking water; (IV) animals receiving 4.7mgCaff/kgbw/day; (V) animals receiving 25mgF/L in drinking water and 4.7mgCaff/kgbw/day. The applied fluoride caused increase of nitric oxide level (NO), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver. Caffeine administered intragastrically, as an antioxidant, was relatively efficient in alleviating these adverse effects of F. In rats treated only with fluoride the F excretion in urine significantly increased in an exposure-time dependent-manner and did not change both in rats treated with Caff and co-exposed to Caff and F.
Journal: Food and Chemical Toxicology - FOOD CHEM TOXICOL , vol. 48, no. 6, pp. 1607-1611, 2010
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...In advanced stages of fluorosis, neurological manifestations such as paralysis of limbs, vertigo, spasticity in extremities and impaired mental acuity are observed in humans (Inkielewicz & Czanowski 2008; Inkielewicz & Krechniak 2004; Mullenix et al...
    • ...As seen in many chronic degenerative diseases, increased production of reactive oxygen species (ROS) and lipid peroxidation has been considered in pathogenesis and recent studies suggest that oxidative stress is a possible pathologic mediating factor in fluoride toxicity (Birkner et al. 2006; Inkielewicz & Czanowski 2008; Krechniak & Inkielewicz 2005), but its occurrence in the developing stages of life during maternal fluoride ...
    • ...Several studies (Chirumari & Reddy 2007; Inkielewicz & Czanowski 2008; Murali & Panneerselvam 2007; Shivashankara et al. 2000; Vani & Reddy 2000) suggest similar results and corroborate the present findings...

    Piler Mahaboob Bashaet al. Effect of maternal exposure of fluoride on oxidative stress markers an...

    • ...In advanced stages of fluorosis, neurological manifestations were observed in humans and animals [3, 4]. The fluoride produces injury to CNS by several mechanisms of particular interest is the ability of fluoride to cause oxidative stress [4-6]...
    • ...Various authors have reported relationship between fluoride and some trace elements [7], trace elements and oxidative stress [8], fluoride and oxidative stress [5, 6, 9, 10]...
    • ...Earlier studies of Inkielewicz and Czanowski indicated that fluoride in varying concentrations induce overdose of free radicals both in fluorosis animal model and humans [5, 6]. Oxidative stress observed in the present study might be resulted in the degradation of certain metal-associated proteins (Cu/Zn binding proteins) and enzyme complexes (metalloproteases, protein kinases, SOD, etc.), which leads to the formation of unbound, unstable, ...

    Madhusudhan Narayanaswamyet al. Effect of Maternal Exposure of Fluoride on Biometals and Oxidative Str...

    • ...Fluoride passes through the placenta and its presence appear in low concentrations in saliva, sweat and milk [2, 3]. Developing animals are more susceptible to fluoride and knockout evidences indicate oxidative stress to be one of the decisive pathologic mediating factors in F toxicity [4, 5]. The products and inescapable by-products of oxidative metabolism can damage macromolecules like nucleic acids, proteins, and lipids [6]...

    Piler Mahaboob Bashaet al. Pre and Post Natal Exposure of Fluoride Induced Oxidative Macromolecul...

Sort by: