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Acupuncture Normalizes Dysfunction of Hypothalamic-Pituitary-Ovarian Axis

Acupuncture Normalizes Dysfunction of Hypothalamic-Pituitary-Ovarian Axis,Bo-Ying Chen

Acupuncture Normalizes Dysfunction of Hypothalamic-Pituitary-Ovarian Axis   (Citations: 32)
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This article summarizes the studies of the mechanism of electroacupuncture (EA) in the regulation of the abnormal function of hypothalamic pituitary-ovarian axis (HPOA) in our laboratory. Clinical observation showed that EA with the effective acupoints could cure some anovulatory patients in a highly effective rate and the experimental results suggested that EA might regulate the dysfunction of HPOA in several ways, which rneans EA could influence some gene expression of brain, thereby, normalizing secretion of some hormones, such as GnRH, LH and E2. The effects of EA might possess a relative specificity on acupoints.
Published in 1997.
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    • ...Acupuncture in specific acupoints has been found to significantly increase blood concentrations of E2 in the ovariectomized rats (35), while reducing the elevated plasma LH due to ovariectomy (36); in addition, acupuncture also restored the number of gonadotropinreleasing hormone (GnRH) neurons in the ovariectomized rats (35)...

    Jue Zhouet al. Acupuncture and Auricular Acupressure in Relieving Menopausal Hot Flas...

    • ... least 2 years whose female partner had had at least two failed intrauterine insemination treatment cycles; [2] a minimum of two pathological spermiograms at an interval of 6 weeks showing oligospermia, asthenospermia, and/or teratozoospermia according to WHO criteria (20); [3] normal values in a baseline endocrine evaluation that measured follicle-stimulating hormone (FSH), LH, prolactin (PRL), estradiol (E2), and testosterone levels; [4] ...
    • ...Exclusion criteria were [1] thyroid dysfunction, adrenal disorders, hyperprolactinemia, or any pathologic hormone parameter; [2] any cause of infertility detectable after systematic physical examination and laboratory testing, including genetic testing; [3] azoospermia; [4] infectious disease or immunologic-associated disease, or presence of any major systemic disease; or [5] abnormal psychological stresses...

    Jian Peiet al. Quantitative evaluation of spermatozoa ultrastructure after acupunctur...

    • ...The effects of repeated low-frequency EA were then attributed to an inhibition of hyperactivity in the sympathetic nervous system [16,32]...

    Luigi Manniet al. Effect of electro-acupuncture on ovarian expression of α (1)- and β (2...

    • ...We have observed that repeated electroacupuncture (EA) in specific acupoints significantly increased blood concentrations of estradiol (E2) in the OVX rats [4], while reducing the elevated plasma luteinizing hormone (LH) due to OVX [5]; in addition, EA also restored the number of gonadotropin-releasing hormone (GnRH) neurons in the OVX rats [4]...
    • ...As a consequence, blood concentrations of ACTH (unpublished data), the activity of adrenal cortex [5] and blood concentration of corticosterone [5] are all elevated...
    • ...As a consequence, blood concentrations of ACTH (unpublished data), the activity of adrenal cortex [5] and blood concentration of corticosterone [5] are all elevated...
    • ...These acupoints are widely applied in Oriental medicine for the treatment of gynaecological disease in women [8] and for the acupuncture mechanism research in the ovariectomized rats [4,5,7,9]...
    • ...In our previous research, we observed the effects of EA on the adrenals of animals, which showed that the mean weight of adrenals in the OVX+EA rats increased significantly than that in the OVX and INT rats [9], and the argyrophilia of NOR proteins (AgNORs) [30] number in reticulate zone of the OVX+EA was considerable more than that of the OVX and INT rats [5], which suggested that the adrenal function might be activated by the EA. In ...
    • ...The results including the changes of blood steroids contents, the tissue aromatase activity and our previous reports [4,5,7,9] suggest that the effects of acupuncture in the regulation of HPOA may be exerted via enhancing the extraglandular aromatization and promoting the function of HPAA, thereby resetting the negative feedback of estrogen to HPOA...

    Hong Zhaoet al. Electroacupuncture enhances extragonadal aromatization in ovariectomiz...

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