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Large Cell Neuroendocrine Carcinoma and Large Cell Carcinomas With Neuroendocrine Morphology of the Lung: Prognosis After Complete Resection and Systematic Nodal Dissection

Large Cell Neuroendocrine Carcinoma and Large Cell Carcinomas With Neuroendocrine Morphology of the Lung: Prognosis After Complete Resection and Syste

Large Cell Neuroendocrine Carcinoma and Large Cell Carcinomas With Neuroendocrine Morphology of the Lung: Prognosis After Complete Resection and Systematic Nodal Dissection   (Citations: 21)
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Background. Large cell neuroendocrine carcinoma (LCNEC) and large cell carcinoma with neuroendocrine morphology of the lung are both currently classified as subtypes of large cell carcinomas according to the World Health Organization IASLC classification system for lung and pleural tumors. Prognosis is reported as similar to that of small cell carcinomas. There is no consensus on management of this subset and adjuvant chemotherapy is recommended by some for early stage LCNEC to impact long-term prognosis. We retrospectively reviewed a cohort of patients at our institution who had this type of tumor to determine factors that might influence survival. Methods. Twenty-one cases of LCNEC and large cell carcinoma with neuroendocrine morphology were iden- tified in the files of the Royal Brompton Hospital be- tween 1986 and 1999. All patient data were reviewed, and complete follow-up was achieved with 20 of these patients. Results. Of the 21 patients identified, 20 underwent resection with systematic nodal dissection in 18. There was no in-hospital mortality. Of those patients fully staged by systematic nodal dissection, 9 were stage I, 5 were stage II and 4 were stage III. Median follow-up was 25 months (range, 2 to 120 months). At the time of review, 11 patients were alive and free of disease. One patient was alive and free of disease when lost to follow-up. Nine patients had died, 7 related and 2 unrelated to disease. The 5-year actuarial survival for the entire group was 47%. The actuarial survival of accurately staged, stage I patients at 5 years was 88%. The actuarial survival of patients in stage II and III was 28% at 5 years. Conclusions. LCNEC and large cell carcinoma with neuroendocrine morphology are aggressive tumors, but patients with completely resected disease after system- atic nodal dissection have a better prognosis than previ- ously described. Patients with more advanced disease have a poor prognosis. (Ann Thorac Surg 2003;75:348 -52) © 2003 by The Society of Thoracic Surgeons
Published in 2010.
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    • ...The 5-years actuarial survival of patients with LCNEC in stage I (27%) was particularly low when compared with the literature [8]...

    Massimiliano Paciet al. Large Cell Neuroendocrine Carcinoma of the Lung: A 10Year Clinicopatho...

    • ...Ortalama izlem süresi olan 19.7 ± 12.5 (3-39) ay boyunca hastalıksız geçen süre ortalama 19 ± 12.9 (3-39) ay olarak bulundu...
    • ...Ortalama izlem süresi olan 19.7 ± 12.5 (3-39) ay boyunca hastalıksız geçen süre ortalama 19 ± 12.9 (3-39) ay olarak bulundu...
    • ...Follow-up period was 19.7 ± 12.5 (3-39) months and disease-free interval was 19 ± 12.9 (3-39) months...
    • ...Follow-up period was 19.7 ± 12.5 (3-39) months and disease-free interval was 19 ± 12.9 (3-39) months...
    • ...Olgularımızdaki ortalama hastalıksız geçen süre 19 ± 12.9 (3-39) ay olarak bulundu...
    • ...BHNK oldukça agresif, kötü prognoza sahip bir tümör olarak tanımlanmıştır ve tedavi stratejisi ile sonuçları halen belirsizliğini korumaktadır (6-9)...
    • ...Erken evre tümörlerde cerrahi tedavinin iyi sonuçlar verdiği çalışmalar mevcuttur (6,12)...

    Alpaslan ÇAKANet al. Akciğerin büyük hücreli nöroendokrin karsinomunda cerrahi tedavi sonuç...

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