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Immuno-Gene Therapy of Established Prostate Tumors Using Chimeric Receptor redirected Human Lymphocytes1

Immuno-Gene Therapy of Established Prostate Tumors Using Chimeric Receptor redirected Human Lymphocytes1,Jehonathan H. Pinthus,Tova Waks,Keren Kaufman

Immuno-Gene Therapy of Established Prostate Tumors Using Chimeric Receptor redirected Human Lymphocytes1   (Citations: 28)
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Targeted adoptive immunotherapy is an attractive option for prostate cancer given its accessible primary location, the presence of specific tissue and tumor antigens, and the acceptability of collateral destruction of healthy prostrate tissue. The "T-body" approach, which uses genetically programmed, patient-derived lymphocytes transfected with chimeric re- ceptor genes, combines the effector functions of T lymphocytes and nat- ural killer cells with the ability of antibodies to recognize predefined surface antigens with high specificity and in a non-MHC restricted man- ner. We evaluated the therapeutic efficacy of anti-erbB2 chimeric recep- tor-bearing human lymphocytes on human prostate cancer xenografts in a SCID mouse model. Local delivery of erbB2-specific T bodies to well- established s.c. and orthotopic tumors, together with systemic administra- tion of interleukin-2, resulted in retardation of both tumor growth and prostate-specific antigen secretion, prolongation of survival, and complete tumor elimination in a significant number of mice. These preclinical studies demonstrate the therapeutic potential of the T-body approach for locally advanced or recurrent prostate cancer as an adjunct to, or after, conventional therapy.
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