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Low Plasma Lycopene Concentration Is Associated With Increased Intima-Media Thickness of the Carotid Artery Wall

Low Plasma Lycopene Concentration Is Associated With Increased Intima-Media Thickness of the Carotid Artery Wall,Tiina Rissanen,Sari Voutilainen,Krist

Low Plasma Lycopene Concentration Is Associated With Increased Intima-Media Thickness of the Carotid Artery Wall   (Citations: 25)
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Although a number of epidemiological studies have evaluated the association between b-carotene and the risk of cardiovascular diseases, there has been little research on the role of lycopene, an acyclic form of b-carotene, with regard to the risk of cardiovascular disease. We investigated the relationship between plasma concentrations of lycopene and intima-media thickness of the common carotid artery wall (CCA-IMT) in 520 middle-aged men and women (aged 45 to 69 years) in eastern Finland. They were examined from 1994 to 1995 at the baseline of the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study, a randomized trial concerning the effect of vitamin E and C supplementation on atherosclerotic progression. The subjects were classified into 2 categories according to the median concentration of plasma lycopene (0.12 mmol/L in men and 0.15 mmol/L in women). Mean CCA-IMT of the right and left common carotid arteries was 1.18 mm in men and 0.95 mm in women with plasma lycopene levels lower than the median and 0.97 mm in men (P,0.001 for difference) and 0.89 mm in women (P50.027 for difference) with higher levels of plasma lycopene. In ANCOVA adjusting for cardiovascular risk factors and intake of nutrients, in men, low levels of plasma lycopene were associated with a 17.8% increment in CCA-IMT (P50.003 for difference). In women, the difference did not remain significant after the adjustments. We conclude that low plasma lycopene concentrations are associated with early atherosclerosis, manifested as increased CCA-IMT, in middle-aged men living in eastern Finland. (Arterioscler Thromb Vasc Biol. 2000;20:2677-2681.)
Published in 2010.
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    • ...Epidemiological and dietary intervention studies suggest that through its antioxidant capacity, lycopene may decrease the risk of infertility (7, 8), diabetes (9, 10), dementia (11, 12), cardiovascular disease (13, 14) and several types of cancer (15-17)...

    E. S. Mackinnonet al. Dietary restriction of lycopene for a period of one month resulted in ...

    • ...Furthermore, both plasma lycopene and lutein are associated with early atherosclerosis, as measured by intima-media thickness [29, 30]...

    Wendy M. R. van Herpen-broekmanset al. Serum carotenoids and vitamins in relation to markers of endothelial f...

    • ...More recently, data from the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study [24,25] indicates significantly thicker common carotid arterial (CCA) intima-media in middleaged men (45 to 69 years of age) with low circulating levels of lycopene...
    • ...Plausible explanations for the latter observation could be either a lower intake of carotenoids in smokers or the dominance of smoking as a major risk factor for atherosclerosis, thereby negating any benefit derived from antioxidants [24,25]...

    Margaret-Mary G. Wilsonet al. Dietary factors in atherogenesis

    • ...Two reports suggest that intimal wall thickness and the risk of MI are lower in persons with higher adipose tissue concentrations of lycopene (7, 8). Another study of Finnish men and women noted similar significant decreases in intimal wall thickness in men but not in women (34)...

    Howard D Sessoet al. Plasma lycopene, other carotenoids, and retinol and the risk of cardio...

    • ...Plasma lycopene ASAP Study, Finnish (42) Cross-sectional F, M 520 IMT Low plasma lycopene concentrations were associated with early atherosclerosis in men...
    • ...Another Finnish study also examined the role of blood concentrations of lycopene with regard to cardiovascular health in women and men living in the eastern part of Finland (42)...

    Sari Voutilainenet al. Carotenoids and cardiovascular health1-3

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