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Noninvasive Arrhythmia Risk Stratification in Idiopathic Dilated Cardiomyopathy Results of the Marburg Cardiomyopathy Study

Noninvasive Arrhythmia Risk Stratification in Idiopathic Dilated Cardiomyopathy Results of the Marburg Cardiomyopathy Study,Wolfram Grimm,Michael Chri

Noninvasive Arrhythmia Risk Stratification in Idiopathic Dilated Cardiomyopathy Results of the Marburg Cardiomyopathy Study   (Citations: 59)
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significant arrhythmia risk predictor in patients with sinus rhythm, with a relative risk of 2.3 per 10% decrease of ejection fraction (95% CI, 1.5 to 3.3; P0.0001). Nonsustained ventricular tachycardia on Holter was associated with a trend toward higher arrhythmia risk (RR, 1.7; 95% CI, 0.9 to 3.3; P0.11), whereas -blocker therapy was associated with a trend toward lower arrhythmia risk (RR, 0.6; 95% CI, 0.3 to 1.2; P0.13). In patients with atrial fibrillation, multivariate Cox analysis also identified LV ejection fraction and absence of -blocker therapy as the only significant arrhythmia risk predictors. Conclusions—Reduced LV ejection fraction and lack of -blocker use are important arrhythmia risk predictors in IDC, whereas signal-averaged ECG, baroreflex sensitivity, heart rate variability, and T-wave alternans do not seem to be helpful for arrhythmia risk stratification. These findings have important implications for the design of future studies evaluating prophylactic implantable cardioverter-defibrillator therapy in IDC. (Circulation. 2003;108:2883-2891.)
Published in 2010.
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