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Interleukin6 Gene Polymorphism and Lipid Abnormalities in Healthy Subjects

Interleukin6 Gene Polymorphism and Lipid Abnormalities in Healthy Subjects,JOSE ´-MANUEL FERNANDEZ-REAL,MONTSERRAT BROCH,JOAN VENDRELL,CRISTOBAL RICHA

Interleukin6 Gene Polymorphism and Lipid Abnormalities in Healthy Subjects   (Citations: 39)
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Several lines of evidence indicate that interleukin-6 (IL-6) is in- volved not only in the hepatic acute phase response but also in adipose tissue metabolism, lipoprotein lipase activity, and hepatic triglycer- ide secretion. A polymorphism in the IL-6 gene, associated with dif- ferences in IL-6 transcription rate, has been recently described. We aimed to study whether this IL-6 gene polymorphism leads to differ- ences in fasting and postglucose load plasma lipids in healthy sub- jects. Subjects with G at position 2174 of the IL-6 gene were similar in age, sex, body mass index, and waist to hip ratio in comparison with carriers of the C allele. However, G carriers showed almost twice plasma triglycerides (1.5 6 0.9 vs. 0.90 6 0.37 mmol/L; P 5 0.01), very low-density lipoprotein (VLDL)-triglycerides (0.97 6 0.69 vs. 0.42 6 0.2 mmol/L; P 5 0.002), higher fasting (881 vs. 458 mmol/L; P 5 0.01), and postglucose load free fatty acids (299 vs. 90.5 mmol/L; P 5 0.03), slightly lower high-density lipoprotein-2 cholesterol (0.25 6 0.14 vs. 0.39 6 0.26 mmol/L; P 5 0.058), and similar cholesterol and LDL- cholesterol levels than carriers of the C allele. Serum IL-6 levels correlated positively with fasting triglycerides, VLDL-triglycerides, and postload free fatty acids (r 5 0.61, 0.65 and 0.60, respectively; P , 0.001) and negatively with high-density lipoprotein-cholesterol (r 5 20.42, P , 0.05). A tendency toward higher serum IL-6 levels was observed among G carriers (9.9 6 6.9 vs. 6.85 6 1.7 pg/mL; P 5 0.09). The 2174G construct was recently reported to show higher expression of IL-6 in He La cells and was associated with higher plasma IL-6 levels than the 2174C allele. Thus, the results of the present study suggest that subjects with the G allele, associated to higher IL-6 secretion, are prone to lipid abnormalities. Whether this polymor- phism contributes to lipid alterations associated with other metabolic disorders awaits additional studies. (J Clin Endocrinol Metab 85: 1334 -1339, 2000)
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