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Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP115 haploinsufficiency to neurodevelopmental abnormalities in mice

Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP115 haploinsufficiency to neurodevelopmental abnormalities in mice,10.10

Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP115 haploinsufficiency to neurodevelopmental abnormalities in mice   (Citations: 79)
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Casper C. Hoogenraad, Bas Koekkoek, Anna Akhmanova, Harm Krugers, Bjorn Dortland, Marja Miedema, Arjan van Alphen, Werner M. Kistler, Martine Jaegle, Manoussos Koutsourakis, Nadja Van Camp, Marleen Verhoyehttp://academic.research.microsoft.com/io.ashx?type=5&id=12971526&selfId1=0&selfId2=0&maxNumber=12&query=
Williams syndrome is a neurodevelopmental disorder caused by the hemizygous deletion of 1.6 Mb on human chromosome 7q11.23. This region comprises the gene CYLN2, encoding CLIP-115, a microtubule-binding protein of 115 kD. Using a gene-targeting approach, we provide evidence that mice with haploinsufficiency for Cyln2 have features reminiscent of Williams syndrome, including mild growth deficiency, brain abnormalities, hippocampal dysfunction and particular deficits in motor coordination. Absence of CLIP-115 also leads to increased levels of CLIP-170 (a closely related cytoplasmic linker protein) and dynactin at the tips of growing microtubules. This protein redistribution may affect dynein motor regulation and, together with the loss of CLIP-115–specific functions, underlie neurological alterations in Williams syndrome.
Journal: Nature Genetics - NAT GENET , vol. 32, no. 1, pp. 116-127, 2002
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