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Endothelial Pulse Amplitude Testing: Feasibility and Reproducibility in Adolescents

Endothelial Pulse Amplitude Testing: Feasibility and Reproducibility in Adolescents,10.1016/j.jpeds.2008.12.028,Journal of Pediatrics,Elif Seda Selame

Endothelial Pulse Amplitude Testing: Feasibility and Reproducibility in Adolescents   (Citations: 11)
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Objectives To test prospectively the reproducibility and feasibility of endothelial pulse amplitude testing (Endo-PAT), a novel Food and Drug Administration-approved technology, in healthy adolescents. Study design We performed Endo-PAT testing on 2 different days separated by no more than 7 days in 30 healthy fasting adolescents, ages 13 to 19 years, to assess reproducibility and feasibility. The reported level of discomfort, as measured on a pain scale of 1 to 5, was documented. Results The mean difference in paired Endo-PAT indices was 0.12 (95% CI, - 0.09-0.33; P.24; intraclass correlation coefficient, 0.78), and the within-subject variation of Endo-PAT index was 0.16. The Endo-PAT index on test days 1 and 2 were 1.91 0.57 and 1.78 0.51 (mean plus or minus SD), respectively. All attempted studies (100%) were completed (95% CI, 88%-100%), and all completed studies (100%) could be analyzed (95% CI, 88%-100%). The median pain score was 1 on both days. Conclusion In healthy adolescents, Endo-PAT is feasible and has excellent reproducibility. This technology may provide an easy and reliable means of assessing endothelial function in the pediatric population. (J Pediatr 2009;154:901-5)
Journal: Journal of Pediatrics - J PEDIAT , vol. 154, no. 6, pp. 901-905, 2009
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