Sequencing technologies — the next generation

Sequencing technologies — the next generation,10.1038/nrg2626,Nature Reviews Genetics,Michael L. Metzker

Sequencing technologies — the next generation   (Citations: 247)
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Demand has never been greater for revolutionary technologies that deliver fast, inexpensive and accurate genome information. This challenge has catalysed the development of next-generation sequencing (NGS) technologies. The inexpensive production of large volumes of sequence data is the primary advantage over conventional methods. Here, I present a technical review of template preparation, sequencing and imaging, genome alignment and assembly approaches, and recent advances in current and near-term commercially available NGS instruments. I also outline the broad range of applications for NGS technologies, in addition to providing guidelines for platform selection to address biological questions of interest.
Journal: Nature Reviews Genetics - NAT REV GENET , vol. 11, no. 1, pp. 31-46, 2009
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